CDH4

Cadherin 4, type 1, R-cadherin (retinal)
Identifiers
Symbols	CDH4 ; CAD4; R-CAD; RCAD
External IDs	OMIM: 603006 MGI: 99218 HomoloGene: 48044 GeneCards: CDH4 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • plasma membrane • integral component of plasma membrane Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • axon guidance • cell junction assembly • adherens junction organization • cell-cell junction organization • positive regulation of axon extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1002	12561
Ensembl	ENSG00000179242	ENSMUSG00000000305
UniProt	P55283	P39038
RefSeq (mRNA)	NM_001252338	NM_009867
RefSeq (protein)	NP_001239267	NP_033997
Location (UCSC)	Chr 20: 61.25 – 61.94 Mb	Chr 2: 179.44 – 179.9 Mb
PubMed search

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.^[1][2][3]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.^[3]

Interactions

Cadherin-4 has been shown to interact with:

• PTPmu^[4]

References

1. Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
2. Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427.
3. "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)".
4. Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H; et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo.". J Cell Biol 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566.

Further reading

• Tagliarini F (1977). "[Relations between social defense and criminological trends from the 1930s until today]". Quaderni di criminologia clinica 18 (3): 289–352. PMID 798233.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
• Tanihara H, Sano K, Heimark RL; et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID 7982033.
• Shan WS, Tanaka H, Phillips GR; et al. (2000). "Functional cis-heterodimers of N- and R-cadherins.". J. Cell Biol. 148 (3): 579–90. doi:10.1083/jcb.148.3.579. PMC 2174798. PMID 10662782.
• Lecanda F, Cheng SL, Shin CS; et al. (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells.". J. Cell. Biochem. 77 (3): 499–506. doi:10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0. PMID 10760957.
• Kitagawa M, Natori M, Murase S; et al. (2000). "Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function.". Biochem. Biophys. Res. Commun. 271 (2): 358–63. doi:10.1006/bbrc.2000.2636. PMID 10799302.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Johnson E, Theisen CS, Johnson KR, Wheelock MJ (2004). "R-cadherin influences cell motility via Rho family GTPases.". J. Biol. Chem. 279 (30): 31041–9. doi:10.1074/jbc.M400024200. PMID 15143071.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miotto E, Sabbioni S, Veronese A; et al. (2005). "Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer.". Cancer Res. 64 (22): 8156–9. doi:10.1158/0008-5472.CAN-04-3000. PMID 15548679.
• Maeda M, Johnson E, Mandal SH; et al. (2006). "Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn).". Oncogene 25 (33): 4595–604. doi:10.1038/sj.onc.1209396. PMID 16786001.

External links

• CDH4 human gene location in the UCSC Genome Browser.
• CDH4 human gene details in the UCSC Genome Browser.