CDH10

Cadherin 10, type 2 (T2-cadherin)
Identifiers
Symbol	CDH10
External IDs	OMIM: 604555 MGI: 107436 HomoloGene: 68530 GeneCards: CDH10 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • plasma membrane • integral component of membrane Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • single organismal cell-cell adhesion • cell junction assembly • adherens junction organization • cell-cell junction organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1008	320873
Ensembl	ENSG00000040731	ENSMUSG00000022321
UniProt	Q9Y6N8	P70408
RefSeq (mRNA)	NM_001190450	NM_009865
RefSeq (protein)	NP_006718	NP_033995
Location (UCSC)	Chr 5: 24.49 – 24.64 Mb	Chr 15: 18.82 – 19.01 Mb
PubMed search

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.^[1][2]

Clinical significance

An association with autism has been suggested.^[3]

See also

• Cadherin
• Heritability of autism

References

1. "Entrez Gene: cadherin 10".
2. Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
3. Wang K, Zhang H, Ma D; et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature 459 (7246): 528–33. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

Further reading

• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rose JE, Behm FM, Drgon T; et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Wang K, Zhang H, Ma D; et al. (2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders.". Nature 459 (7246): 528–33. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.
• Potkin SG, Guffanti G, Lakatos A; et al. (2009). "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.". PLoS ONE 4 (8): e6501. doi:10.1371/journal.pone.0006501. PMC 2719581. PMID 19668339.
• Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex.". J. Comp. Neurol. 453 (4): 372–88. doi:10.1002/cne.10424. PMID 12389209.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999). "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.". FEBS Lett. 452 (3): 328–34. doi:10.1016/S0014-5793(99)00672-9. PMID 10386616.
• Hillier LD, Lennon G, Becker M; et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.". Microcirculation 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219.
• Ma D, Salyakina D, Jaworski JM; et al. (2009). "A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.". Ann. Hum. Genet. 73 (Pt 3): 263–73. doi:10.1111/j.1469-1809.2009.00523.x. PMC 2918410. PMID 19456320.
• Hülsken J, Birchmeier W, Behrens J (1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.". J. Cell Biol. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.