Poliovirus receptor-related 3

Poliovirus receptor-related 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4FOM​
Identifiers
Symbols	PVRL3 ; CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3
External IDs	OMIM: 607147 HomoloGene: 9162 GeneCards: PVRL3 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell adherens junction • apical junction complex • postsynaptic membrane Biological process • lens morphogenesis in camera-type eye • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • fertilization • single organismal cell-cell adhesion • cell junction assembly • adherens junction organization • cell-cell junction organization • retina morphogenesis in camera-type eye Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25945	58998
Ensembl	ENSG00000177707	ENSMUSG00000022656
UniProt	Q9NQS3	Q9JLB9
RefSeq (mRNA)	NM_001243286	NM_021495
RefSeq (protein)	NP_001230215	NP_067470
Location (UCSC)	Chr 3: 111.07 – 111.28 Mb	Chr 16: 46.39 – 46.5 Mb
PubMed search

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.^[1]

Function

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM]^[1]

Interactions

PVRL3 has been shown to interact with:

• MLLT4,^[2][3]
• PARD3,^[4]
• PTPRM.^[5]

See also

• Cluster of differentiation

References

1. "Entrez Gene: PVRL3 poliovirus receptor-related 3".
2. Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
3. Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. doi:10.1016/s0378-1119(00)00316-4. PMID 11024295.
4. Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
5. Sakamoto Y, Ogita H, Komura H, Takai Y. "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion". J. Biol. Chem. 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016.

Further reading

• Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
• Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295.
• Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
• Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
• Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains". J. Biol. Chem. 278 (33): 31251–60. doi:10.1074/jbc.M304166200. PMID 12759359.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Fujito T, Ikeda W, Kakunaga S, Minami Y, Kajita M, Sakamoto Y, Monden M, Takai Y (2005). "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMC 2171219. PMID 16216929.

External links

• PVRL3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.