MST1R

Macrophage stimulating 1 receptor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3PLS​, 4FWW​, 4QT8​
Identifiers
Symbols	MST1R ; CD136; CDw136; PTK8; RON
External IDs	OMIM: 600168 MGI: 99614 HomoloGene: 1835 ChEMBL: 2689 GeneCards: MST1R Gene
EC number	2.7.10.1
Gene ontology Molecular function • macrophage colony-stimulating factor receptor activity • protein binding • ATP binding • enzyme binding Cellular component • stress fiber • integral component of plasma membrane • cell surface Biological process • movement of cell or subcellular component • defense response • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • single fertilization • positive regulation of cell proliferation • response to virus • peptidyl-tyrosine phosphorylation • macrophage colony-stimulating factor signaling pathway • positive regulation of MAP kinase activity • innate immune response • positive regulation of protein kinase B signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4486	19882
Ensembl	ENSG00000164078	ENSMUSG00000032584
UniProt	Q04912	Q62190
RefSeq (mRNA)	NM_001244937	NM_001287261
RefSeq (protein)	NP_001231866	NP_001274190
Location (UCSC)	Chr 3: 49.89 – 49.9 Mb	Chr 9: 107.91 – 107.92 Mb
PubMed search

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.^[1][2] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.^[1][3]

Interactions

MST1R has been shown to interact with Grb2.^[4][5]

References

1. Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene 8 (5): 1195–202. PMID 8386824.
2. "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".
3. Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829.
4. Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
5. Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464.

Further reading

• Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
• Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science 266 (5182): 117–9. doi:10.1126/science.7939629. PMID 7939629.
• Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829.
• Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene 8 (12): 3403–10. PMID 8247543.
• Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype". Mol. Cell. Biol. 16 (10): 5518–26. PMC 231551. PMID 8816464.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464.
• Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
• Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene 19 (27): 3041–9. doi:10.1038/sj.onc.1203620. PMID 10871856.
• Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo". Oncogene 21 (41): 6382–6. doi:10.1038/sj.onc.1205783. PMID 12214279.
• Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais". Carcinogenesis 23 (11): 1811–9. doi:10.1093/carcin/23.11.1811. PMID 12419829.
• Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential". Oncogene 22 (2): 186–97. doi:10.1038/sj.onc.1206075. PMID 12527888.
• Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. doi:10.1073/pnas.0837136100. PMC 153598. PMID 12676986.
• Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. 27 (6): 779–85. doi:10.1097/00000478-200306000-00008. PMID 12766581.
• Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene 22 (24): 3669–79. doi:10.1038/sj.onc.1206585. PMID 12802274.
• Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res. 288 (2): 382–9. doi:10.1016/S0014-4827(03)00250-7. PMID 12915129.
• Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
• Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
• van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood 103 (12): 4457–65. doi:10.1182/blood-2003-08-2713. PMID 14982882.
• Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett. 20 (9): 2745–9. doi:10.1016/j.bmcl.2010.03.073.