BMX (gene)

BMX non-receptor tyrosine kinase
Rendering based on PDB 2EKX​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EKX​, 2YS2​, 3SXR​, 3SXS​
Identifiers
Symbols	BMX ; ETK; PSCTK2; PSCTK3
External IDs	OMIM: 300101 MGI: 1101778 HomoloGene: 20411 ChEMBL: 3834 GeneCards: BMX Gene
EC number	2.7.10.2
Gene ontology Molecular function • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • signal transducer activity • receptor binding • protein binding • ATP binding • metal ion binding Cellular component • cytosol • extrinsic component of cytoplasmic side of plasma membrane • ruffle membrane Biological process • adaptive immune response • protein phosphorylation • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • cell adhesion • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • mesoderm development • programmed cell death • cell differentiation • intracellular signal transduction • peptidyl-tyrosine autophosphorylation • regulation of cell proliferation • innate immune response • protein autophosphorylation • T cell receptor signaling pathway • B cell receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	660	12169
Ensembl	ENSG00000102010	ENSMUSG00000031377
UniProt	P51813	P97504
RefSeq (mRNA)	NM_001721	NM_009759
RefSeq (protein)	NP_001712	NP_033889
Location (UCSC)	Chr X: 15.46 – 15.56 Mb	Chr X: 164.19 – 164.26 Mb
PubMed search

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.^[1][2]

Function

Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.^[2]

Interactions

BMX has been shown to interact with:

• PAK1,^[3]
• PTK2,^[4]
• PTPN21^[5] and
• RUFY1.^[6]

References

1. Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (December 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene 9 (12): 3683–8. PMID 7970727.
2. "Entrez Gene: BMX BMX non-receptor tyrosine kinase".
3. Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (August 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
4. Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (May 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870.
5. Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (December 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
6. Yang J, Kim O, Wu J, Qiu Y (August 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.

Further reading

• Robinson D, He F, Pretlow T, Kung HJ (1996). "A tyrosine kinase profile of prostate carcinoma". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 5958–62. doi:10.1073/pnas.93.12.5958. PMC 39170. PMID 8650201.
• Kaukonen J, Lahtinen I, Laine S; et al. (1996). "BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias". Br. J. Haematol. 94 (3): 455–60. PMID 8790141.
• Ekman N, Lymboussaki A, Västrik I; et al. (1997). "Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries". Circulation 96 (6): 1729–32. doi:10.1161/01.cir.96.6.1729. PMID 9323053.
• Saharinen P, Ekman N, Sarvas K; et al. (1997). "The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta". Blood 90 (11): 4341–53. PMID 9373245.
• Qiu Y, Robinson D, Pretlow TG, Kung HJ (1998). "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3644–9. doi:10.1073/pnas.95.7.3644. PMC 19889. PMID 9520419.
• Várnai P, Rother KI, Balla T (1999). "Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells". J. Biol. Chem. 274 (16): 10983–9. doi:10.1074/jbc.274.16.10983. PMID 10196179.
• Tsai YT, Su YH, Fang SS; et al. (2000). "Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation". Mol. Cell. Biol. 20 (6): 2043–54. doi:10.1128/MCB.20.6.2043-2054.2000. PMC 110821. PMID 10688651.
• Ekman N, Arighi E, Rajantie I; et al. (2000). "The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner". Oncogene 19 (36): 4151–8. doi:10.1038/sj.onc.1203763. PMID 10962576.
• Jui HY, Tseng RJ, Wen X; et al. (2001). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
• Wu YM, Huang CL, Kung HJ, Huang CY (2001). "Proteolytic activation of ETK/Bmx tyrosine kinase by caspases". J. Biol. Chem. 276 (21): 17672–8. doi:10.1074/jbc.M010964200. PMID 11278797.
• Chen R, Kim O, Li M; et al. (2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870.
• Bagheri-Yarmand R, Mandal M, Taludker AH; et al. (2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
• Vargas L, Nore BF, Berglof A; et al. (2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. 277 (11): 9351–7. doi:10.1074/jbc.M108537200. PMID 11751885.
• Yang J, Kim O, Wu J, Qiu Y (2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
• Pan S, An P, Zhang R; et al. (2002). "Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis". Mol. Cell. Biol. 22 (21): 7512–23. doi:10.1128/MCB.22.21.7512-7523.2002. PMC 135657. PMID 12370298.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nore BF, Mattsson PT, Antonsson P; et al. (2003). "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases". Biochim. Biophys. Acta 1645 (2): 123–32. doi:10.1016/S1570-9639(02)00524-1. PMID 12573241.
• Zhang R, Xu Y, Ekman N; et al. (2004). "Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway". J. Biol. Chem. 278 (51): 51267–76. doi:10.1074/jbc.M310678200. PMID 14532277.
• Chen KY, Huang LM, Kung HJ; et al. (2004). "The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells". Oncogene 23 (10): 1854–62. doi:10.1038/sj.onc.1207308. PMID 14676838.