TXK (gene)

TXK tyrosine kinase
PDB rendering based on 2dm0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DM0​
Identifiers
Symbols	TXK ; BTKL; PSCTK5; PTK4; RLK; TKL
External IDs	OMIM: 600058 MGI: 102960 HomoloGene: 2497 ChEMBL: 4367 GeneCards: TXK Gene
EC number	2.7.10.2
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II regulatory region DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • non-membrane spanning protein tyrosine kinase activity • receptor binding • protein binding • ATP binding Cellular component • nucleus • cytoplasm • extrinsic component of cytoplasmic side of plasma membrane Biological process • cytokine production • adaptive immune response • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • protein phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • activation of phospholipase C activity • T cell differentiation • positive regulation of interferon-gamma production • peptidyl-tyrosine autophosphorylation • regulation of cell proliferation • innate immune response • positive regulation of transcription from RNA polymerase II promoter • protein autophosphorylation • T cell receptor signaling pathway • B cell receptor signaling pathway • positive regulation of interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7294	22165
Ensembl	ENSG00000074966	ENSMUSG00000054892
UniProt	P42681	P42682
RefSeq (mRNA)	NM_003328	NM_001122754
RefSeq (protein)	NP_003319	NP_001116226
Location (UCSC)	Chr 4: 48.07 – 48.13 Mb	Chr 5: 72.7 – 72.75 Mb
PubMed search

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.^[1][2][3]

References

1. Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet 3 (6): 897–901. doi:10.1093/hmg/3.6.897. PMID 7951233.
2. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
3. "Entrez Gene: TXK TXK tyrosine kinase".

Further reading

• Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.". Clinical medicine & research 4 (2): 147–51. doi:10.3121/cmr.4.2.147. PMC 1483892. PMID 16809408.
• Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.". Oncogene 12 (4): 937–42. PMID 8632917.
• Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.". J. Biol. Chem. 271 (33): 19641–4. doi:10.1074/jbc.271.33.19641. PMID 8702662.
• Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.". Immunity 6 (2): 155–64. doi:10.1016/S1074-7613(00)80422-7. PMID 9047237.
• Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.". Biochem. Biophys. Res. Commun. 252 (1): 14–9. doi:10.1006/bbrc.1998.9559. PMID 9813138.
• Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
• Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.". J. Biol. Chem. 275 (6): 3835–40. doi:10.1074/jbc.275.6.3835. PMID 10660534.
• Chamorro M, Czar MJ, Debnath J, et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.". BMC Immunol. 2: 3. doi:10.1186/1471-2172-2-3. PMC 31577. PMID 11353545.
• Takeba Y, Nagafuchi H, Takeno M, et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.". J. Immunol. 168 (5): 2365–70. doi:10.4049/jimmunol.168.5.2365. PMID 11859127.
• Kashiwakura J, Suzuki N, Takeno M, et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.". Biol. Pharm. Bull. 25 (6): 718–21. doi:10.1248/bpb.25.718. PMID 12081135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.