EPH receptor B1

EPH receptor B1
PDB rendering based on 2djs.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DJS​, 2EAO​, 3ZFX​
Identifiers
Symbols	EPHB1 ; ELK; EPHT2; Hek6; NET
External IDs	OMIM: 600600 MGI: 1096337 HomoloGene: 20936 ChEMBL: 5072 GeneCards: EPHB1 Gene
EC number	2.7.10.1
Gene ontology Molecular function • transmembrane-ephrin receptor activity • protein binding • ATP binding • axon guidance receptor activity • protein complex binding Cellular component • extracellular region • cytosol • plasma membrane • integral component of plasma membrane • axon • dendrite • early endosome membrane • filopodium tip • membrane raft • extracellular exosome Biological process • angiogenesis • immunological synapse formation • axon guidance • peptidyl-tyrosine phosphorylation • optic nerve morphogenesis • central nervous system projection neuron axonogenesis • neurogenesis • establishment of cell polarity • retinal ganglion cell axon guidance • cell-substrate adhesion • regulation of JNK cascade • protein autophosphorylation • ephrin receptor signaling pathway • camera-type eye morphogenesis • detection of temperature stimulus involved in sensory perception of pain • positive regulation of synapse assembly • cell chemotaxis • dendritic spine development • dendritic spine morphogenesis • neural precursor cell proliferation • regulation of ERK1 and ERK2 cascade • regulation of neuron death Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2047	270190
Ensembl	ENSG00000154928	ENSMUSG00000032537
UniProt	P54762	Q8CBF3
RefSeq (mRNA)	NM_004441	NM_001168296
RefSeq (protein)	NP_004432	NP_001161768
Location (UCSC)	Chr 3: 134.6 – 135.26 Mb	Chr 9: 101.92 – 102.35 Mb
PubMed search

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.^[1][2]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[2]

Interactions

EPH receptor B1 has been shown to interact with:

• ACP1,^[3]
• GRB7,^[4] and
• NCK1.^[5]

References

1. Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (1995). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics 29 (2): 426–37. doi:10.1006/geno.1995.9985. PMID 8666391.
2. "Entrez Gene: EPHB1 EPH receptor B1".
3. Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO (Mar 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. 12 (5): 667–78. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.
4. Han DC, Shen TL, Miao H, Wang B, Guan JL (Nov 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. 277 (47): 45655–61. doi:10.1074/jbc.M203165200. PMID 12223469.
5. Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (Jan 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". J. Biol. Chem. 273 (3): 1303–8. doi:10.1074/jbc.273.3.1303. PMID 9430661.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Abrahamson DR, Robert B, Hyink DP, St John PL, Daniel TO (1998). "Origins and formation of microvasculature in the developing kidney". Kidney Int. Suppl. 67: S7–11. doi:10.1046/j.1523-1755.1998.06702.x. PMID 9736245.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2000). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Larose L, Gish G, Shoelson S, Pawson T (1993). "Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1". Oncogene 8 (9): 2493–9. PMID 7689724.
• Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science 266 (5186): 816–9. doi:10.1126/science.7973638. PMID 7973638.
• Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors". EMBO J. 13 (16): 3757–62. PMC 395287. PMID 8070404.
• Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. 32 (16): 1197–205. doi:10.1016/0161-5890(95)00108-5. PMID 8559144.
• Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells". J. Biol. Chem. 271 (38): 23588–93. doi:10.1074/jbc.271.38.23588. PMID 8798570.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine 9 (8): 540–9. doi:10.1006/cyto.1997.0199. PMID 9245480.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". J. Biol. Chem. 273 (3): 1303–8. doi:10.1074/jbc.273.3.1303. PMID 9430661.
• Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO (1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. 12 (5): 667–78. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.