EPH receptor A1

EPH receptor A1
PDB rendering based on 1x5a.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2K1K​, 2K1L​, 3HIL​, 3KKA​
Identifiers
Symbols	EPHA1 ; EPH; EPHT; EPHT1
External IDs	OMIM: 179610 MGI: 107381 HomoloGene: 3835 ChEMBL: 5810 GeneCards: EPHA1 Gene
EC number	2.7.10.1
Gene ontology Molecular function • protein kinase activity • transmembrane-ephrin receptor activity • ATP binding • protein kinase binding Cellular component • plasma membrane • integral component of plasma membrane Biological process • angiogenesis • positive regulation of cell-matrix adhesion • negative regulation of protein kinase activity • cell surface receptor signaling pathway • axon guidance • positive regulation of cell proliferation • peptidyl-tyrosine phosphorylation • positive regulation of cell migration • negative regulation of cell migration • substrate adhesion-dependent cell spreading • somatic stem cell maintenance • regulation of GTPase activity • positive regulation of angiogenesis • protein autophosphorylation • ephrin receptor signaling pathway • positive regulation of stress fiber assembly • activation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2041	13835
Ensembl	ENSG00000146904	ENSMUSG00000029859
UniProt	P21709	Q60750
RefSeq (mRNA)	NM_005232	NM_023580
RefSeq (protein)	NP_005223	NP_076069
Location (UCSC)	Chr 7: 143.39 – 143.41 Mb	Chr 6: 42.36 – 42.37 Mb
PubMed search

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.^[1][2]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.^[2]

References

1. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
2. "Entrez Gene: EPHA1 EPH receptor A1".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Hirai H, Maru Y, Hagiwara K; et al. (1988). "A novel putative tyrosine kinase receptor encoded by the eph gene.". Science 238 (4834): 1717–20. doi:10.1126/science.2825356. PMID 2825356.
• Gale NW, Holland SJ, Valenzuela DM; et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Owshalimpur D, Kelley MJ (1999). "Genomic structure of the EPHA1 receptor tyrosine kinase gene.". Mol. Cell. Probes 13 (3): 169–73. doi:10.1006/mcpr.1999.0228. PMID 10369740.
• Kalo MS, Pasquale EB (October 1999). "Signal transfer by eph receptors". Cell and tissue research 298 (1): 1–9. doi:10.1007/pl00008807. PMID 10502115.
• Coulthard MG, Lickliter JD, Subanesan N; et al. (2002). "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues.". Growth Factors 18 (4): 303–17. doi:10.3109/08977190109029118. PMID 11519828.
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.