EPH receptor B4

EPH receptor B4
PDB rendering based on 2bba.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2BBA​, 2E7H​, 2HLE​, 2QKQ​, 2VWU​, 2VWV​, 2VWW​, 2VWX​, 2VWY​, 2VWZ​, 2VX0​, 2VX1​, 2X9F​, 2XVD​, 2YN8​, 3ZEW​, 4AW5​, 4BB4​
Identifiers
Symbols	EPHB4 ; HTK; MYK1; TYRO11
External IDs	OMIM: 600011 MGI: 104757 HomoloGene: 20939 ChEMBL: 5147 GeneCards: EPHB4 Gene
EC number	2.7.10.1
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • ephrin receptor activity • protein binding • ATP binding Cellular component • extracellular region • cytosol • plasma membrane • integral component of plasma membrane • extracellular exosome Biological process • angiogenesis • cell migration involved in sprouting angiogenesis • heart morphogenesis • cell adhesion • axon guidance • peptidyl-tyrosine phosphorylation • protein autophosphorylation • ephrin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2050	13846
Ensembl	ENSG00000196411	ENSMUSG00000029710
UniProt	P54760	P54761
RefSeq (mRNA)	NM_004444	NM_001159571
RefSeq (protein)	NP_004435	NP_001153043
Location (UCSC)	Chr 7: 100.8 – 100.83 Mb	Chr 5: 137.35 – 137.38 Mb
PubMed search

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.^[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.^[2][3]

References

1. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem 269 (19): 14211–8. PMID 8188704.
2. "Entrez Gene: EPHB4 EPH receptor B4".
3. Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.". Mol. Cell 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Andres AC, Reid HH, Zürcher G; et al. (1994). "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.". Oncogene 9 (5): 1461–7. PMID 8152808.
• Berclaz G, Andres AC, Albrecht D; et al. (1996). "Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.". Biochem. Biophys. Res. Commun. 226 (3): 869–75. doi:10.1006/bbrc.1996.1442. PMID 8831703.
• Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Nikolova Z, Djonov V, Zuercher G; et al. (1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis.". J. Cell. Sci. 111 (18): 2741–51. PMID 9718367.
• Tang XX, Brodeur GM, Campling BG, Ikegaki N (1999). "Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.". Clin. Cancer Res. 5 (2): 455–60. PMID 10037197.
• Dalva MB, Takasu MA, Lin MZ; et al. (2001). "EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.". Cell 103 (6): 945–56. doi:10.1016/S0092-8674(00)00197-5. PMID 11136979.
• Wilson MD, Riemer C, Martindale DW; et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.