ABL2

ABL proto-oncogene 2, non-receptor tyrosine kinase
PDB rendering based on 1ab2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ECD​, 2KK1​, 2XYN​, 3GVU​, 3HMI​, 3ULR​, 4EIH​
Identifiers
Symbols	ABL2 ; ABLL; ARG
External IDs	OMIM: 164690 MGI: 87860 HomoloGene: 5278 ChEMBL: 4014 GeneCards: ABL2 Gene
EC number	2.7.10.2
Gene ontology Molecular function • magnesium ion binding • actin monomer binding • protein kinase activity • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • receptor binding • protein binding • ATP binding • manganese ion binding • actin filament binding Cellular component • phagocytic cup • cytosol • actin cytoskeleton • lamellipodium • extrinsic component of cytoplasmic side of plasma membrane • dendritic spine Biological process • cellular protein modification process • phagocytosis • substrate-dependent cell migration, cell extension • signal transduction • epidermal growth factor receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • axon guidance • visual learning • regulation of autophagy • positive regulation of phospholipase C activity • positive regulation of neuron projection development • neuron remodeling • cell migration • peptidyl-tyrosine phosphorylation • cerebellum morphogenesis • negative regulation of cell-cell adhesion • regulation of endocytosis • cell differentiation • regulation of cell adhesion • positive regulation of protein binding • cellular protein localization • negative regulation of Rho protein signal transduction • exploration behavior • peptidyl-tyrosine autophosphorylation • regulation of cell proliferation • regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • alpha-beta T cell differentiation • platelet-derived growth factor receptor signaling pathway • dendrite morphogenesis • neuromuscular process controlling balance • actin filament bundle assembly • positive regulation of oxidoreductase activity • Bergmann glial cell differentiation • positive regulation of ERK1 and ERK2 cascade • cellular response to retinoic acid • dendritic spine maintenance • positive regulation of interleukin-2 secretion • positive regulation of interferon-gamma secretion • regulation of extracellular matrix organization • positive regulation of Wnt signaling pathway, planar cell polarity pathway • regulation of cell motility • regulation of actin cytoskeleton reorganization • negative regulation of endothelial cell apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27	11352
Ensembl	ENSG00000143322	ENSMUSG00000026596
UniProt	P42684	Q4JIM5
RefSeq (mRNA)	NM_001136000	NM_001136104
RefSeq (protein)	NP_001129472	NP_001129576
Location (UCSC)	Chr 1: 179.1 – 179.23 Mb	Chr 1: 156.56 – 156.65 Mb
PubMed search

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.^[1][2]

Function

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.^[2]

Interactions

ABL2 has been shown to interact with three proteins: Abl gene,^[3] catalase,^[4] and SORBS2.^[5] The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.^[6] Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.^[7] SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.^[5][8][2]

References

1. Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
2. "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
3. Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
4. Cao C, Leng Y, Kufe D (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. 278 (32): 29667–75. doi:10.1074/jbc.M301292200. PMID 12777400.
5. Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
6. Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science 253 (5019): 562–5. doi:10.1126/science.1857987. PMID 1857987.
7. Chelikani P, Fita I, Loewen PC (January 2004). "Diversity of structures and properties among catalases". Cell. Mol. Life Sci. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. PMID 14745498.
8. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

Further reading

• Bradley, WD, Koleske AJ (2009). "Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts.". J Cell Sci 122: 3441–54. doi:10.1242/jcs.039859. PMC 2746129. PMID 19759284.
• Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling.". Adv. Cancer Res. 85: 51–100. doi:10.1016/S0065-230X(02)85003-5. PMID 12374288.
• Muller AJ, Pendergast AM, Havlik MH; et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.". Mol. Cell. Biol. 12 (11): 5087–93. PMC 360442. PMID 1383690.
• Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. doi:10.1073/pnas.87.15.5802. PMC 54416. PMID 2198571.
• Kruh GD, King CR, Kraus MH; et al. (1987). "A novel human gene closely related to the abl proto-oncogene.". Science 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene 13 (1): 193–7. PMID 8700546.
• Wang B, Mysliwiec T, Feller SM; et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene 13 (7): 1379–85. PMID 8875975.
• Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Koval AP, Blakesley VA, Roberts CT; et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". Biochem. J. 330 (2): 923–32. PMC 1219226. PMID 9480911.
• Hashimoto Y, Katayama H, Kiyokawa E; et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27): 17186–91. doi:10.1074/jbc.273.27.17186. PMID 9642287.
• Danial NN, Losman JA, Lu T; et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Mol. Cell. Biol. 18 (11): 6795–804. PMC 109263. PMID 9774693.
• Cao C, Ren X, Kharbanda S; et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
• Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.
• Endo A, Nagashima K, Kurose H; et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". J. Biol. Chem. 277 (26): 23747–54. doi:10.1074/jbc.M111794200. PMID 11956190.
• Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". EMBO J. 21 (17): 4571–82. doi:10.1093/emboj/cdf446. PMC 126186. PMID 12198159.
• Bianchi C, Muradore I, Corizzato M; et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Lett. 527 (1–3): 216–222. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salomon AR, Ficarro SB, Brill LM; et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.

External links

• Genes, abl at the US National Library of Medicine Medical Subject Headings (MeSH)
• Abelson Leukemia Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
• ABL2 Info with links in the Cell Migration Gateway