EPHA6

EPH receptor A6
Identifiers
Symbols	EPHA6 ; EHK-2; EHK2; EK12; EPA6; HEK12; PRO57066
External IDs	OMIM: 600066 MGI: 108034 HomoloGene: 56396 ChEMBL: 4526 GeneCards: EPHA6 Gene
EC number	2.7.10.1
Gene ontology Molecular function • molecular_function • ephrin receptor activity • ATP binding Cellular component • cellular_component • nucleoplasm • plasma membrane • integral component of plasma membrane Biological process • axon guidance • biological_process • peptidyl-tyrosine phosphorylation • ephrin receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	285220	13840
Ensembl	ENSG00000080224	ENSMUSG00000055540
UniProt	Q9UF33	Q62413
RefSeq (mRNA)	NM_001080448	NM_007938
RefSeq (protein)	NP_001073917	NP_031964
Location (UCSC)	Chr 3: 96.81 – 97.75 Mb	Chr 16: 59.65 – 60.61 Mb
PubMed search

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.^[1][2]

References

1. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.
2. "Entrez Gene: EPHA6 EPH receptor A6".

Further reading

• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance.". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683.
• Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain.". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
• Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
• Gale NW, Holland SJ, Valenzuela DM; et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Aasheim HC, Munthe E, Funderud S; et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.". Blood 95 (1): 221–30. PMID 10607706.
• Prevost N, Woulfe D, Tanaka T, Brass LF (2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9219–24. doi:10.1073/pnas.142053899. PMC 123121. PMID 12084815.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hafner C, Schmitz G, Meyer S; et al. (2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers.". Clin. Chem. 50 (3): 490–9. doi:10.1373/clinchem.2003.026849. PMID 14726470.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.