TEC (gene)

Tec protein tyrosine kinase

PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TEC ; PSCTK4
External IDs OMIM: 600583 MGI: 98662 HomoloGene: 1302 ChEMBL: 4246 GeneCards: TEC Gene
EC number 2.7.10.2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7006 21682
Ensembl ENSG00000135605 ENSMUSG00000029217
UniProt P42680 P24604
RefSeq (mRNA) NM_003215 NM_001113460
RefSeq (protein) NP_003206 NP_001106931
Location (UCSC) Chr 4:
48.14 – 48.27 Mb		 Chr 5:
72.76 – 72.87 Mb
PubMed search

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

Function

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]

Interactions

TEC (gene) has been shown to interact with:

References

  1. ↑ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72. PMID 7934162.
  2. 1 2 "Entrez Gene: TEC tec protein tyrosine kinase".
  3. 1 2 Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  4. 1 2 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (Nov 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood 96 (10): 3406–13. PMID 11071635.
  5. ↑ Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology 14 (12): 8432–7. PMC 359382. PMID 7526158.
  6. ↑ Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.
  7. ↑ Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
  8. ↑ Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood 91 (5): 1496–507. PMID 9473212.
  9. ↑ Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.

Further reading

  • Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews 10 (3-4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781. 
  • Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735. 
  • Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene 5 (12): 1781–6. PMID 2284097. 
  • Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology 14 (12): 8432–7. PMC 359382. PMID 7526158. 
  • Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene 11 (4): 619–25. PMID 7651724. 
  • Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal 10 (5): 637–42. PMID 8621063. 
  • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002. 
  • Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736. 
  • Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene 12 (4): 937–42. PMID 8632917. 
  • Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology 157 (9): 3791–5. PMID 8892607. 
  • Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903. 
  • Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487. 
  • Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood 91 (3): 940–8. PMID 9446655. 
  • Yang WC, Ghiotto M, Barbarat B, Olive D (Jan 1999). "The role of Tec protein-tyrosine kinase in T cell signaling". The Journal of Biological Chemistry 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994. 
  • Yang WC, Olive D (Jun 1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". European Journal of Immunology 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746. 
  • Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proceedings of the National Academy of Sciences of the United States of America 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561. 


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