GNA12

Guanine nucleotide binding protein (G protein) alpha 12
PDB rendering based on 1zca.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1zca​
Identifiers
Symbols	GNA12 ; NNX3; RMP; gep
External IDs	OMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12 Gene
Gene ontology Molecular function • GTPase activity • signal transducer activity • protein binding • GTP binding • G-protein beta/gamma-subunit complex binding • D5 dopamine receptor binding • metal ion binding Cellular component • heterotrimeric G-protein complex • plasma membrane • focal adhesion • brush border membrane Biological process • in utero embryonic development • G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • Rho protein signal transduction • blood coagulation • metabolic process • regulation of cell shape • regulation of fibroblast migration • cell differentiation • platelet activation • regulation of TOR signaling • regulation of proteasomal ubiquitin-dependent protein catabolic process • response to drug • embryonic digit morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2768	14673
Ensembl	ENSG00000146535	ENSMUSG00000000149
UniProt	Q03113	P27600
RefSeq (mRNA)	NM_001282440	NM_010302
RefSeq (protein)	NP_001269369	NP_034432
Location (UCSC)	Chr 7: 2.73 – 2.84 Mb	Chr 5: 140.76 – 140.83 Mb
PubMed search

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.^[1][2][3]

Interactions

GNA12 has been shown to interact with ARHGEF1,^[4] PPP5C,^[5] ARHGEF12,^[6][7] Heat shock protein 90kDa alpha (cytosolic), member A1^[8] and TEC.^[7]

See also

• G12/G13 alpha subunits

References

1. Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800.
2. Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
3. "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
4. Johnson EN, Seasholtz TM, Waheed AA; et al. (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
5. Yamaguchi, Yoshiaki; Katoh Hironori; Mori Kazutoshi; Negishi Manabu (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. (England) 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367.
6. Fukuhara, S; Chikumi H; Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164.
7. Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866.
8. Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". J. Biol. Chem. (United States) 276 (49): 46088–93. doi:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136.

External links

• GNA12 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)