GNAT3

Guanine nucleotide binding protein, alpha transducing 3

Identifiers

GNAT3 ; GDCA

External IDs

OMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3 Gene

2.3.1.4

Gene ontology
Molecular function	• G-protein coupled receptor binding • GTPase activity • signal transducer activity • GTP binding • G-protein beta/gamma-subunit complex binding • metal ion binding
Cellular component	• acrosomal vesicle • photoreceptor outer segment • photoreceptor inner segment • heterotrimeric G-protein complex • plasma membrane • axoneme • apical plasma membrane • protein complex
Biological process	• detection of chemical stimulus involved in sensory perception of bitter taste • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • synaptic transmission • blood coagulation • metabolic process • platelet activation • response to nicotine • sensory perception of sweet taste • sensory perception of umami taste
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
80.46 – 80.51 Mb

Chr 5:
17.96 – 18.02 Mb

PubMed search

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein that in humans is encoded by the GNAT3 gene.^[1]

Gustducin alpha-3 chain is a subunit of the heterotrimeric protein gustducin that is responsible for basic taste.

References

↑ "Entrez Gene: guanine nucleotide binding protein".

Oldham WM, Van Eps N, Preininger AM; et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID 16892066.
Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Rozengurt N, Wu SV, Chen MC; et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792–802. doi:10.1152/ajpgi.00074.2006. PMID 16728727.
Huang L, Shanker YG, Dubauskaite J; et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481.
Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029.
Margolskee RF, Dyer J, Kokrashvili Z; et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi:10.1073/pnas.0706678104. PMC 1986615. PMID 17724332.
Takami S, Getchell TV, McLaughlin SK; et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.". Brain Res. Mol. Brain Res. 22 (1-4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379.
Jang HJ, Kokrashvili Z, Theodorakis MJ; et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMC 1986614. PMID 17724330.
Li X, Staszewski L, Xu H; et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
Fehr J, Meyer D, Widmayer P; et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.". J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID 17021831.
Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.". Nature 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID 8208289.

Intracellular signaling peptides and proteins

MAP

see MAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A

cGMP:	Transducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G

G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16

G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2

G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Other protein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor-associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1

Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK

both	Dual-specificity kinase

Other protein phosphatase

Serine/threonine:	Protein phosphatase 2

Tyrosine:	protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase

both:	Dual-specificity phosphatase

Apoptosis

see apoptosis signaling pathway

GTP-binding protein regulators

see GTP-binding protein regulators

Other

see also deficiencies of intracellular signaling peptides and proteins

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GNAT3

References

Further reading