GNA13

Guanine nucleotide binding protein (G protein), alpha 13
PDB rendering based on 1zcb.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1zcb​
Identifiers
Symbols	GNA13 ; G13
External IDs	OMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCards: GNA13 Gene
Gene ontology Molecular function • GTPase activity • signal transducer activity • protein binding • GTP binding • G-protein beta/gamma-subunit complex binding • type 1 angiotensin receptor binding • D5 dopamine receptor binding • metal ion binding Cellular component • nucleus • cytosol • heterotrimeric G-protein complex • plasma membrane • focal adhesion • membrane • brush border membrane • melanosome • extracellular exosome Biological process • patterning of blood vessels • in utero embryonic development • movement of cell or subcellular component • signal transduction • adenylate cyclase-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • Rho protein signal transduction • blood coagulation • metabolic process • regulation of cell shape • cell differentiation • platelet activation • regulation of cell migration • activation of phospholipase D activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10672	14674
Ensembl	ENSG00000120063	ENSMUSG00000020611
UniProt	Q14344	P27601
RefSeq (mRNA)	NM_001282425	NM_010303
RefSeq (protein)	NP_001269354	NP_034433
Location (UCSC)	Chr 17: 65.01 – 65.06 Mb	Chr 11: 109.36 – 109.4 Mb
PubMed search

Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.^[1][2]

Interactions

GNA13 has been shown to interact with:

• AKAP3,^[3]
• ARHGEF12,^[4][5]
• ARHGEF1,^[6][7][8]
• RIC8A,^[9] and
• Radixin.^[10]

Clinical significance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.^[11][12]

See also

• G protein

References

1. Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Mar 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744.
2. "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13".
3. Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology 11 (21): 1686–90. doi:10.1016/s0960-9822(01)00530-9. PMID 11696326.
4. Fukuhara S, Chikumi H, Gutkind JS (Nov 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters 485 (2-3): 183–8. doi:10.1016/s0014-5793(00)02224-9. PMID 11094164.
5. Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
6. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
7. Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Letters 540 (1-3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510.
8. Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
9. Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
10. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
11. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
12. Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

Further reading

• Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR (Jun 2005). "Essential role for Galpha13 in endothelial cells during embryonic development". Proceedings of the National Academy of Sciences of the United States of America 102 (23): 8281–8286. doi:10.1073/pnas.0503326102. PMC 1149452. PMID 15919816.
• Downes GB, Gautam N (Dec 1999). "The G protein subunit gene families". Genomics 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457. Check date values in: |year= / |date= mismatch (help)
• Offermanns S, Laugwitz KL, Spicher K, Schultz G (Jan 1994). "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the National Academy of Sciences of the United States of America 91 (2): 504–8. doi:10.1073/pnas.91.2.504. PMC 42977. PMID 8290554.
• Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
• Offermanns S, Hu YH, Simon MI (Oct 1996). "Galpha12 and galpha13 are phosphorylated during platelet activation". The Journal of Biological Chemistry 271 (42): 26044–8. doi:10.1074/jbc.271.42.26044. PMID 8824244.
• Offermanns S, Mancino V, Revel JP, Simon MI (Jan 1997). "Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency". Science 275 (5299): 533–6. doi:10.1126/science.275.5299.533. PMID 8999798.
• Macrez-Leprêtre N, Kalkbrenner F, Morel JL, Schultz G, Mironneau J (Apr 1997). "G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes". The Journal of Biological Chemistry 272 (15): 10095–102. doi:10.1074/jbc.272.15.10095. PMID 9092554.
• Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
• Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS (Feb 1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". The Journal of Biological Chemistry 274 (9): 5868–79. doi:10.1074/jbc.274.9.5868. PMID 10026210.
• Becker KP, Garnovskaya M, Gettys T, Halushka PV (Jul 1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling". Biochimica et Biophysica Acta 1450 (3): 288–96. doi:10.1016/S0167-4889(99)00068-3. PMID 10395940.
• Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR (Sep 1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". The Journal of Biological Chemistry 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan PJ, Nanoff C, Strosberg AD, Jockers R (Dec 1999). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Molecular Endocrinology (Baltimore, Md.) 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579. Check date values in: |year= / |date= mismatch (help)
• Bhattacharyya R, Wedegaertner PB (May 2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". The Journal of Biological Chemistry 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.
• Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
• Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH (Aug 2000). "G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription". The Journal of Biological Chemistry 275 (32): 24470–6. doi:10.1074/jbc.M908449199. PMID 10821841.
• Ponimaskin E, Behn H, Adarichev V, Voyno-Yasenetskaya TA, Offermanns S, Schmidt MF (Jul 2000). "Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation". FEBS Letters 478 (1-2): 173–7. doi:10.1016/S0014-5793(00)01845-7. PMID 10922491.
• Jin S, Exton JH (Nov 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
• Fukuhara S, Chikumi H, Gutkind JS (Nov 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters 485 (2-3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
• Meigs TE, Fields TA, McKee DD, Casey PJ (Jan 2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release". Proceedings of the National Academy of Sciences of the United States of America 98 (2): 519–24. doi:10.1073/pnas.021350998. PMC 14619. PMID 11136230.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.