PAK4

P21 protein (Cdc42/Rac)-activated kinase 4

PDB rendering based on 2bva.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol PAK4
External IDs OMIM: 605451 MGI: 1917834 HomoloGene: 4300 ChEMBL: 4482 GeneCards: PAK4 Gene
EC number 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10298 70584
Ensembl ENSG00000130669 ENSMUSG00000030602
UniProt O96013 Q8BTW9
RefSeq (mRNA) NM_001014831 NM_027470
RefSeq (protein) NP_001014831 NP_081746
Location (UCSC) Chr 19:
39.13 – 39.18 Mb		 Chr 7:
28.4 – 28.6 Mb
PubMed search

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.[1][2][3]

Function

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3] PAK4 has been shown to be repressed at translational level by miR-24.[4]

Interactions

PAK4 has been shown to interact with CDC42,[1][5][6] Integrin, beta 5[7] and LIMK1.[8]

References

  1. 1 2 Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A (Nov 1998). "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia". The EMBO Journal 17 (22): 6527–40. doi:10.1093/emboj/17.22.6527. PMC 1171000. PMID 9822598.
  2. ↑ Bagrodia S, Cerione RA (Sep 1999). "Pak to the future". Trends in Cell Biology 9 (9): 350–5. doi:10.1016/S0962-8924(99)01618-9. PMID 10461188.
  3. 1 2 "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4".
  4. ↑ Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G (Oct 2012). "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration". The Journal of Cell Biology 199 (2): 347–63. doi:10.1083/jcb.201203134. PMID 23071155.
  5. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  6. ↑ Dan C, Nath N, Liberto M, Minden A (Jan 2002). "PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells". Molecular and Cellular Biology 22 (2): 567–77. doi:10.1128/MCB.22.2.567-577.2002. PMC 139731. PMID 11756552.
  7. ↑ Zhang H, Li Z, Viklund EK, Strömblad S (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". The Journal of Cell Biology 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMC 2173231. PMID 12356872.
  8. ↑ Dan C, Kelly A, Bernard O, Minden A (Aug 2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". The Journal of Biological Chemistry 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130.

Further reading

External links


This article is issued from Wikipedia - version of the Friday, November 27, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.