ATP2A3

ATPase, Ca++ transporting, ubiquitous
Identifiers
Symbols	ATP2A3 ; SERCA3
External IDs	OMIM: 601929 MGI: 1194503 HomoloGene: 69131 ChEMBL: 2401 GeneCards: ATP2A3 Gene
EC number	3.6.3.8
Gene ontology Molecular function • calcium-transporting ATPase activity • ATP binding • metal ion binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane • sarcoplasmic reticulum • platelet dense tubular network membrane • nuclear membrane • sarcoplasmic reticulum membrane Biological process • transport • calcium ion transport • blood coagulation • metabolic process • ion transmembrane transport • transmembrane transport • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	489	53313
Ensembl	ENSG00000074370	ENSMUSG00000020788
UniProt	Q93084	Q64518
RefSeq (mRNA)	NM_005173	NM_001163336
RefSeq (protein)	NP_005164	NP_001156808
Location (UCSC)	Chr 17: 3.92 – 3.96 Mb	Chr 11: 72.96 – 72.99 Mb
PubMed search

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.^[1][2]

This gene encodes one of the SERCA Ca²⁺-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.^[2]

References

1. Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca²⁺-ATPase 3 gene". Biochem J 318 (2): 689–99. PMC 1217674. PMID 8809064.
2. "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous".

Further reading

• Wuytack F, Papp B, Verboomen H; et al. (1994). "A sarco/endoplasmic reticulum Ca²⁺-ATPase 3-type Ca²⁺ pump is expressed in platelets, in lymphoid cells, and in mast cells". J. Biol. Chem. 269 (2): 1410–6. PMID 8288608.
• Dode L, De Greef C, Mountian I; et al. (1998). "Structure of the human sarco/endoplasmic reticulum Ca²⁺-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA". J. Biol. Chem. 273 (22): 13982–94. doi:10.1074/jbc.273.22.13982. PMID 9593748.
• Poch E, Leach S, Snape S; et al. (1999). "Functional characterization of alternatively spliced human SERCA3 transcripts". Am. J. Physiol. 275 (6 Pt 1): C1449–58. PMID 9843705.
• Martin V, Bredoux R, Corvazier E; et al. (2002). "Three novel sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family". J. Biol. Chem. 277 (27): 24442–52. doi:10.1074/jbc.M202011200. PMID 11956212.
• Gélébart P, Kovács T, Brouland JP; et al. (2002). "Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation". J. Biol. Chem. 277 (29): 26310–20. doi:10.1074/jbc.M201747200. PMID 11986315.
• Dode L, Vilsen B, Van Baelen K; et al. (2003). "Dissection of the functional differences between sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses". J. Biol. Chem. 277 (47): 45579–91. doi:10.1074/jbc.M207778200. PMID 12207029.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Houston R (2003). "Longitudinal sections of unfixed muscle". Biotechnic & histochemistry : official publication of the Biological Stain Commission 77 (4): 229–30. PMID 12503734.
• Borge PD, Wolf BA (2003). "Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells". J. Biol. Chem. 278 (13): 11359–68. doi:10.1074/jbc.M209521200. PMID 12524443.
• Chandrasekera CP, Lytton J (2003). "Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction". J. Biol. Chem. 278 (14): 12482–8. doi:10.1074/jbc.M212745200. PMID 12540840.
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Bobe R, Bredoux R, Corvazier E; et al. (2004). "Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca²⁺ATPase 3 gene". J. Biol. Chem. 279 (23): 24297–306. doi:10.1074/jbc.M314286200. PMID 15028735.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brouland JP, Gélébart P, Kovàcs T; et al. (2005). "The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis". Am. J. Pathol. 167 (1): 233–42. doi:10.1016/S0002-9440(10)62968-9. PMC 1603437. PMID 15972967.
• Hadri L, Pavoine C, Lipskaia L; et al. (2006). "Transcription of the sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells". Biochem. J. 394 (Pt 1): 27–33. doi:10.1042/BJ20051387. PMC 1385999. PMID 16250893.
• Wootton LL, Michelangeli F (2006). "The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA) Ca²⁺ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors". J. Biol. Chem. 281 (11): 6970–6. doi:10.1074/jbc.M510978200. PMID 16410239.
• Chaâbane C, Corvazier E, Bredoux R; et al. (2006). "Sarco/endoplasmic reticulum Ca²⁺ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress". Biochem. Biophys. Res. Commun. 345 (4): 1377–85. doi:10.1016/j.bbrc.2006.05.054. PMID 16725111.
• Bredoux R, Corvazier E, Dally S; et al. (2006). "Human platelet Ca²⁺-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis". Platelets 17 (6): 421–33. doi:10.1080/09537100600758719. PMID 16973504.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.