ATP10A

ATPase, class V, type 10A
Identifiers
Symbols	ATP10A ; ATP10C; ATPVA; ATPVC
External IDs	OMIM: 605855 MGI: 1330809 HomoloGene: 56461 GeneCards: ATP10A Gene
EC number	3.6.3.1
Gene ontology Molecular function • magnesium ion binding • phospholipid-translocating ATPase activity • protein binding • ATP binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • integral component of membrane Biological process • intracellular protein transport • metabolic process • regulation of cell shape • ion transmembrane transport • phospholipid translocation • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57194	11982
Ensembl	ENSG00000206190	ENSMUSG00000025324
UniProt	O60312	O54827
RefSeq (mRNA)	NM_024490	NM_009728
RefSeq (protein)	NP_077816	NP_033858
Location (UCSC)	Chr 15: 25.68 – 25.87 Mb	Chr 7: 58.66 – 58.83 Mb
PubMed search

Probable phospholipid-transporting ATPase VA also known as ATPase class V type 10A (ATP10A) or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.^[1][2][3]

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'.^[3]

See also

• Haloacid dehydrogenase superfamily

References

1. Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Oct 2000). "Differential expression of putative transbilayer amphipath transporters". Physiol Genomics 1 (3): 139–50. PMID 11015572.
2. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
3. "Entrez Gene: ATP10A ATPase, Class V, type 10A".

Further reading

• Kato C, Tochigi M, Ohashi J, et al. (2008). "Association study of the 15q11-q13 maternal expression domain in Japanese autistic patients". American Journal of Medical Genetics 147b (7): 1008–12. doi:10.1002/ajmg.b.30690. PMID 18186074.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dhar M, Hauser L, Johnson D (2003). "An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes". Obes. Res. 10 (7): 695–702. doi:10.1038/oby.2002.94. PMID 12105293.
• Herzing LB, Kim SJ, Cook EH, Ledbetter DH (2001). "The Human Aminophospholipid-Transporting ATPase Gene ATP10C Maps Adjacent to UBE3A and Exhibits Similar Imprinted Expression". Am. J. Hum. Genet. 68 (6): 1501–5. doi:10.1086/320616. PMC 1226137. PMID 11353404.
• Meguro M, Kashiwagi A, Mitsuya K, et al. (2001). "A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome". Nat. Genet. 28 (1): 19–20. doi:10.1038/88209. PMID 11326269.
• Gillessen-Kaesbach G, Demuth S, Thiele H, et al. (1999). "A previously unrecognised phenotype characterised by obesity, muscular hypotonia, and ability to speak in patients with Angelman syndrome caused by an imprinting defect". European Journal of Human Genetics 7 (6): 638–44. doi:10.1038/sj.ejhg.5200362. PMID 10482951.