Haloacid dehydrogenase superfamily

Hydrolase_3

crystal structure of had-like phosphatase yida from e. coli
Identifiers
Symbol Hydrolase_3
Pfam PF08282
Pfam clan CL0137
InterPro IPR013200

In molecular biology, the haloacid dehydrogenase superfamily (HAD superfamily) includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.[1]

Examples

A HAD domain is found in several distinct enzymes including:

Human genes encoding proteins that contain this domain include:

References

  1. Koonin EV, Tatusov RL (November 1994). "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search". J. Mol. Biol. 244 (1): 125–32. doi:10.1006/jmbi.1994.1711. PMID 7966317.
  2. Gomes E, Jakobsen MK, Axelsen KB, Geisler M, Palmgren MG (December 2000). "Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases". Plant Cell 12 (12): 2441–2454. doi:10.2307/3871240. PMC 102229. PMID 11148289.
  3. Wu J, Woodard RW (May 2003). "Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase". J. Biol. Chem. 278 (20): 18117–23. doi:10.1074/jbc.M301983200. PMID 12639950.
  4. Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS (November 2001). "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes". J. Biol. Chem. 276 (47): 43580–8. doi:10.1074/jbc.M108054200. PMID 11562374.
  5. Kim Y, Yakunin AF, Kuznetsova E, Xu X, Pennycooke M, Gu J, Cheung F, Proudfoot M, Arrowsmith CH, Joachimiak A, Edwards AM, Christendat D (January 2004). "Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum". J. Biol. Chem. 279 (1): 517–26. doi:10.1074/jbc.M306054200. PMC 2795321. PMID 14555659.

This article incorporates text from the public domain Pfam and InterPro IPR013200

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