Protein-synthesizing GTPase

Protein-synthesizing GTPases (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation into protein by the ribosome, with systematic name GTP phosphohydrolase (mRNA-translation-assisting).^[1]^[2]^[3]^[4]^[5] They usually include translation initiation factors such as IF-2 and translation elongation factors such as EF-Tu.

References

↑ Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). "GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2". FEBS Lett. 175 (2): 313–316. doi:10.1016/0014-5793(84)80758-9. PMID 6566615.
↑ Kisselev, L.L. and Frolova, L.Yu. (1995). "Termination of translation in eukaryotes". Biochem. Cell Biol. 73 (11-12): 1079–1086. doi:10.1139/o95-116. PMID 8722024.
↑ Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). "Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome". Nature 385 (6611): 37–41. doi:10.1038/385037a0. PMID 8985244.
↑ Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). "Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner". EMBO J. 16: 4126–4133. doi:10.1093/emboj/16.13.4126. PMID 9233821.
↑ Krab, I.M. and Parmeggiani, A. (1998). "EF-Tu, a GTPase odyssey". Biochim. Biophys. Acta 1443 (1-2): 1–22. doi:10.1016/s0167-4781(98)00169-9. PMID 9838020.

External links

Protein-synthesizing GTPase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2

Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_αi GNAI1 GNAI2 GNAI3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13 Transducin GNAT1 GNAT2

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin Tubulin

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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