Olfactory marker protein

olfactory marker protein
Identifiers
Symbol	OMP
Entrez	4975
HUGO	8136
OMIM	164340
RefSeq	NM_006189
UniProt	P47874
Other data
Locus	Chr. 11 q14-q21

Olfactory marker protein
solution structure of olfactory marker protein from rat
Identifiers
Symbol	Olfactory_mark
Pfam	PF06554
InterPro	IPR009103
SCOP	1jyt
SUPERFAMILY	1jyt
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.^[1] Three highly conserved regions have been identified as possible protein–protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.^[2]

External links

• Olfactory marker protein at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1. Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873.
2. Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872.

This article incorporates text from the public domain Pfam and InterPro IPR009103