SCG5

Secretogranin V
Identifiers
Symbols	SCG5 ; 7B2; P7B2; SGNE1; SgV
External IDs	OMIM: 173120 MGI: 98289 HomoloGene: 37722 GeneCards: SCG5 Gene
Gene ontology Molecular function • enzyme inhibitor activity • protein binding • GTP binding • unfolded protein binding Cellular component • extracellular region • secretory granule Biological process • intracellular protein transport • neuropeptide signaling pathway • peptide hormone processing • negative regulation of catalytic activity • regulation of hormone secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6447	20394
Ensembl	ENSG00000166922	ENSMUSG00000023236
UniProt	P05408	P12961
RefSeq (mRNA)	NM_001144757	NM_009162
RefSeq (protein)	NP_001138229	NP_033188
Location (UCSC)	Chr 15: 32.64 – 32.7 Mb	Chr 2: 113.78 – 113.83 Mb
PubMed search

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.^[1][2][3] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.^[4][5] It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.

References

1. Lloyd RV, Jin L (May 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254.
2. Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671.
3. Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
4. "Entrez Gene: SCG5 secretogranin V (7B2 protein)".
5. Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.

Further reading

• Mbikay M, Seidah NG, Chrétien M (2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions.". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.
• Paquet L, Lazure C, Seidah NG, et al. (1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.". Biochem. Biophys. Res. Commun. 174 (1): 156–62. doi:10.1016/0006-291X(91)90499-W. PMID 1989596.
• Roebroek AJ, Dehaen MR, van Bokhoven A, et al. (1989). "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization.". Cytogenet. Cell Genet. 50 (2–3): 158–60. doi:10.1159/000132749. PMID 2776483.
• Benjannet S, Marcinkiewicz M, Falgueyret JP, et al. (1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors". Endocrinology 123 (2): 874–84. doi:10.1210/endo-123-2-874. PMID 2840270.
• Martens GJ (1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
• Brayton KA, Aimi J, Qiu H, et al. (1989). "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein". DNA 7 (10): 713–9. doi:10.1089/dna.1988.7.713. PMID 3234177.
• Marcinkiewicz M, Benjannet S, Falgueyret JP, et al. (1988). "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma". Endocrinology 123 (2): 866–73. doi:10.1210/endo-123-2-866. PMID 3293987.
• Marcinkiewicz M, Benjannet S, Cantin M, et al. (1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Res. 380 (2): 349–56. doi:10.1016/0006-8993(86)90233-7. PMID 3530373.
• Seidah NG, Hsi KL, De Serres G, et al. (1983). "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus". Arch. Biochem. Biophys. 225 (2): 525–34. doi:10.1016/0003-9861(83)90063-2. PMID 6625600.
• Benjannet S, Savaria D, Chrétien M, Seidah NG (1995). "7B2 is a specific intracellular binding protein of the prohormone convertase PC2". J. Neurochem. 64 (5): 2303–11. doi:10.1046/j.1471-4159.1995.64052303.x. PMID 7722516.
• Braks JA, Martens GJ (1994). "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway". Cell 78 (2): 263–73. doi:10.1016/0092-8674(94)90296-8. PMID 7913882.
• Braks JA, Broers CA, Danger JM, Martens GJ (1996). "Structural organization of the gene encoding the neuroendocrine chaperone 7B2". Eur. J. Biochem. 236 (1): 60–7. doi:10.1111/j.1432-1033.1996.00060.x. PMID 8617287.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bourdeau I, Antonini SR, Lacroix A, et al. (2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators". Oncogene 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Dasgupta I, Sanglas L, Enghild JJ, Lindberg I. (2012). "The neuroendocrine protein 7B2 is intrinsically disordered.". Biochemistry 51 (38): 7456–64. doi:10.1021/bi300871k. PMID 22947085.
• Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, Eriksen JL, Lindberg I. (2013). "The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins..". J Biol Chem 288 (2): 1114–247. doi:10.1074/jbc.M112.417071. PMID 23172224.