Calgranulin

Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

Human genes

S100A8 (calgranulin A)
S100A9 (calgranulin B)
S100A12 (calgranulin C)

Function

Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.^[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.

References

↑ Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol 275 (2 Pt 2): F255–61. PMID 9691016.

External links

Calgranulin A at the US National Library of Medicine Medical Subject Headings (MeSH)
Calgranulin B at the US National Library of Medicine Medical Subject Headings (MeSH)

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Ion pumps	SERCA Sodium-calcium exchanger

Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor

Adhesion molecules	Cadherin

Other	Calcium-sensing receptor

Intracellular signaling
& calc. regulation

Second messengers	IP3 NAADP cADPR

Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor

Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS

Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins

Proteases	Calpain

Cytoskeleton remodeling proteins	Gelsolin

Chaperones	Calreticulin Calnexin

Other	Vitamin D

Calcium-binding
protein domains

Extracellular ligands

Calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin

Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin

Cytoskeleton	Troponin C

Extracellular matrix	Matrix gla protein

Protein: nerve tissue protein

Synuclein	Alpha-synuclein Beta-synuclein Gamma-synuclein

Other	Agrin Chimerin Granin Chromogranin A B FMR1 Gap-43 protein GLUT3 Myelin Brain natriuretic peptide Nerve growth factor SCG5 Neurogranin Neuronal calcium sensor Neuropeptide Olfactory marker protein S100 protein Calgranulin Synapsin 1 2 3 Synaptophysin Tubulin GPM6A

Surface antigens

Major histocompatibility complex/
Human leukocyte antigen

MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G

MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5 Minor histocompatibility antigen

Other

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Calgranulin

Human genes

Function

References

See also

External links