FBLN2

Fibulin 2
Identifiers
Symbol	FBLN2
External IDs	OMIM: 135821 MGI: 95488 HomoloGene: 1514 GeneCards: FBLN2 Gene
Gene ontology Molecular function • extracellular matrix structural constituent • calcium ion binding • extracellular matrix binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular matrix • extracellular exosome • extracellular vesicle Biological process • positive regulation of cell-substrate adhesion • extracellular matrix organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2199	14115
Ensembl	ENSG00000163520	ENSMUSG00000064080
UniProt	P98095	P37889
RefSeq (mRNA)	NM_001004019	NM_001081437
RefSeq (protein)	NP_001004019	NP_001074906
Location (UCSC)	Chr 3: 13.55 – 13.64 Mb	Chr 6: 91.21 – 91.27 Mb
PubMed search

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.^[1][2]

This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

Interactions

FBLN2 has been shown to interact with Laminin, alpha 1,^[3][4] Laminin, alpha 5^[3] and Perlecan.^[5][6]

References

1. Zhang RZ, Pan TC, Zhang ZY, Mattei MG, Timpl R, Chu ML (January 1995). "Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes". Genomics 22 (2): 425–30. doi:10.1006/geno.1994.1404. PMID 7806230.
2. "Entrez Gene: FBLN2 fibulin 2".
3. Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. (UNITED STATES) 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. ISSN 0021-9258. PMID 9006922.
4. Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. (UNITED STATES) 275 (45): 35192–9. doi:10.1074/jbc.M003261200. ISSN 0021-9258. PMID 10934193.
5. Hopf, M; Göhring W; Mann K; Timpl R (August 2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan". J. Mol. Biol. (England) 311 (3): 529–41. doi:10.1006/jmbi.2001.4878. ISSN 0022-2836. PMID 11493006.
6. Sasaki, T; Göhring W; Pan T C; Chu M L; Timpl R (December 1995). "Binding of mouse and human fibulin-2 to extracellular matrix ligands". J. Mol. Biol. (ENGLAND) 254 (5): 892–9. doi:10.1006/jmbi.1995.0664. ISSN 0022-2836. PMID 7500359.

Further reading

• Sasaki T, Göhring W, Pan TC; et al. (1996). "Binding of mouse and human fibulin-2 to extracellular matrix ligands.". J. Mol. Biol. 254 (5): 892–9. doi:10.1006/jmbi.1995.0664. PMID 7500359.
• Pan TC, Sasaki T, Zhang RZ; et al. (1994). "Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding". J. Cell Biol. 123 (5): 1269–77. doi:10.1083/jcb.123.5.1269. PMC 2119879. PMID 8245130.
• Reinhardt DP, Sasaki T, Dzamba BJ; et al. (1996). "Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues". J. Biol. Chem. 271 (32): 19489–96. doi:10.1074/jbc.271.32.19489. PMID 8702639.
• Miosge N, Götz W, Sasaki T; et al. (1996). "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo". Histochem. J. 28 (2): 109–16. doi:10.1007/BF02331415. PMID 8737292.
• Collod G, Chu ML, Sasaki T; et al. (1997). "Fibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2". Eur. J. Hum. Genet. 4 (5): 292–5. PMID 8946175.
• Utani A, Nomizu M, Yamada Y (1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. PMID 9006922.
• Sasaki T, Mann K, Wiedemann H; et al. (1997). "Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge". EMBO J. 16 (11): 3035–43. doi:10.1093/emboj/16.11.3035. PMC 1169922. PMID 9214621.
• Brown JC, Sasaki T, Göhring W; et al. (1998). "The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans". Eur. J. Biochem. 250 (1): 39–46. doi:10.1111/j.1432-1033.1997.t01-1-00039.x. PMID 9431988.
• Raghunath M, Tschödrich-Rotter M, Sasaki T; et al. (1999). "Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration". J. Invest. Dermatol. 112 (1): 97–101. doi:10.1046/j.1523-1747.1999.00483.x. PMID 9886271.
• Kuivaniemi H, Marshall A, Ganguly A; et al. (1999). "Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms". Eur. J. Hum. Genet. 6 (6): 642–6. doi:10.1038/sj.ejhg.5200245. PMID 9887386.
• Sasaki T, Göhring W, Miosge N; et al. (1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Lett. 460 (2): 280–4. doi:10.1016/S0014-5793(99)01362-9. PMID 10544250.
• Gu YC, Nilsson K, Eng H, Ekblom M (2000). "Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma". Br. J. Haematol. 109 (2): 305–13. doi:10.1046/j.1365-2141.2000.02011.x. PMID 10848816.
• Talts JF, Sasaki T, Miosge N; et al. (2001). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. 275 (45): 35192–9. doi:10.1074/jbc.M003261200. PMID 10934193.
• Olin AI, Mörgelin M, Sasaki T; et al. (2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". J. Biol. Chem. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
• Hopf M, Göhring W, Mann K, Timpl R (2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan". J. Mol. Biol. 311 (3): 529–41. doi:10.1006/jmbi.2001.4878. PMID 11493006.
• Hunzelmann N, Nischt R, Brenneisen P; et al. (2001). "Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres". Br. J. Dermatol. 145 (2): 217–22. doi:10.1046/j.1365-2133.2001.04337.x. PMID 11531782.
• Sasaki T, Göhring W, Mann K; et al. (2002). "Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins". J. Mol. Biol. 314 (4): 751–63. doi:10.1006/jmbi.2001.5176. PMID 11733994.
• Bengtsson E, Mörgelin M, Sasaki T; et al. (2002). "The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor". J. Biol. Chem. 277 (17): 15061–8. doi:10.1074/jbc.M108285200. PMID 11847210.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.