Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc.^[1] All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.^[2]

Members of NCS family

Highly evolutionarily conserved ^[3]
NCS1 (Frequenin)
VILIP-1 (Visinin-like-protein-1)
HPCAL4 (Visinin-like-protein-2)
HPCAL1 (Visinin-like-protein-3)
hippocalcin
neurocalcin
recoverin
Guanylate cyclase activator proteins (GCAPs)
Potassium Channel interacting proteins (KChIPs 1-4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

References

↑ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
↑ Weiss JL, Hui H, Burgoyne RD (2010). "Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.". Cell Mol Neurobiol. 30 (8): 1283–92. doi:10.1007/s10571-010-9588-7. PMID 21104311.

External links

Neuronal Calcium-Sensor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
NCS proteins

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Ion pumps	SERCA Sodium-calcium exchanger

Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor

Adhesion molecules	Cadherin

Other	Calcium-sensing receptor

Intracellular signaling
& calc. regulation

Second messengers	IP3 NAADP cADPR

Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor

Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS

Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins

Proteases	Calpain

Cytoskeleton remodeling proteins	Gelsolin

Chaperones	Calreticulin Calnexin

Other	Vitamin D

Calcium-binding
protein domains

Extracellular ligands

Calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin

Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin

Cytoskeleton	Troponin C

Extracellular matrix	Matrix gla protein

Protein: nerve tissue protein

Synuclein	Alpha-synuclein Beta-synuclein Gamma-synuclein

Other	Agrin Chimerin Granin Chromogranin A B FMR1 Gap-43 protein GLUT3 Myelin Brain natriuretic peptide Nerve growth factor SCG5 Neurogranin Neuronal calcium sensor Neuropeptide Olfactory marker protein S100 protein Calgranulin Synapsin 1 2 3 Synaptophysin Tubulin GPM6A

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