Guanylate cyclase activator

For the drugs, see cinaciguat and riociguat.

A guanylate cyclase activator (or "GUCA") is one of group of proteins which upregulates guanylate cyclase. It is also known as guanylate cyclase-activating protein, with the abbreviation "GCAP".Mutations can be associated with vision defects.^[1]

There are five genes involved:

GUCA1A, GUCA1B, GUCA1C
GUCA2A, GUCA2B

References

↑ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.

External links

Guanylate Cyclase-Activating Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

Eye proteins

Opsin (retinylidene protein)

visual	Rhodopsin Photopsin (OPN1LW OPN1MW/OPN1MW2 OPN1SW)

nonvisual	Melanopsin OPN3 OPN5 RRH RGR

Crystallin

Alpha (A
B)
Beta (A1
A2
A4
B1
B2
B3)
Gamma (A
B
C
D
N
S)

Other

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