KCNIP2

Kv channel interacting protein 2
Identifiers
Symbols	KCNIP2 ; KCHIP2
External IDs	OMIM: 604661 HomoloGene: 23710 GeneCards: KCNIP2 Gene
Gene ontology Molecular function • A-type (transient outward) potassium channel activity • calcium ion binding • protein binding • potassium channel regulator activity • identical protein binding • ion channel binding • ER retention sequence binding • protein N-terminus binding Cellular component • cytoplasm • voltage-gated potassium channel complex Biological process • detection of calcium ion • potassium ion transport • muscle contraction • signal transduction • synaptic transmission • regulation of heart contraction • clustering of voltage-gated potassium channels • potassium ion export • potassium ion transmembrane transport • membrane repolarization • regulation of potassium ion transmembrane transport • regulation of cation channel activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30819	80906
Ensembl	ENSG00000120049	ENSMUSG00000025221
UniProt	Q9NS61	Q9JJ69
RefSeq (mRNA)	NM_014591	NM_001276358
RefSeq (protein)	NP_055406	NP_001263287
Location (UCSC)	Chr 10: 101.83 – 101.84 Mb	Chr 19: 45.79 – 45.82 Mb
PubMed search

K_v channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.^[1][2]

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[2]

See also

• Voltage-gated potassium channel

References

1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
2. "Entrez Gene: KCNIP2 Kv channel interacting protein 2".
3. Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y (Mar 2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochemical and Biophysical Research Communications 282 (1): 96–102. doi:10.1006/bbrc.2001.4558. PMID 11263977.
• Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D (Jun 2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". The Journal of Biological Chemistry 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421.
• Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D (May 2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle". The Journal of Physiology 533 (Pt 1): 119–25. doi:10.1111/j.1469-7793.2001.0119b.x. PMC 2278594. PMID 11351020.
• Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K, Wollnik B (Nov 2001). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant". Cardiovascular Research 52 (2): 255–64. doi:10.1016/S0008-6363(01)00374-1. PMID 11684073.
• Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR (Dec 2001). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia". Cell 107 (6): 801–13. doi:10.1016/S0092-8674(01)00588-8. PMID 11747815.
• Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF (Jul 2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation 106 (4): 423–9. doi:10.1161/01.CIR.0000025417.65658.B6. PMID 12135940.
• Deschênes I, Tomaselli GF (Sep 2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Letters 528 (1-3): 183–8. doi:10.1016/S0014-5793(02)03296-9. PMID 12297301.
• Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS (Sep 2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". The Journal of Biological Chemistry 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.
• Ren X, Shand SH, Takimoto K (Oct 2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". The Journal of Biological Chemistry 278 (44): 43564–70. doi:10.1074/jbc.M302337200. PMID 12928444.
• Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA (Feb 2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2". The Journal of Biological Chemistry 279 (7): 5549–54. doi:10.1074/jbc.M311332200. PMID 14623880.
• Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N (Feb 2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution". Neuron 41 (4): 513–9. doi:10.1016/S0896-6273(04)00050-9. PMID 14980201.
• Lin YL, Lin SR, Wu TT, Chang LS (Jul 2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochemical and Biophysical Research Communications 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
• Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS (Sep 2004). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain". The Journal of Neuroscience 24 (36): 7903–15. doi:10.1523/JNEUROSCI.0776-04.2004. PMID 15356203.
• Lin YL, Chen CY, Cheng CP, Chang LS (Aug 2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochemical and Biophysical Research Communications 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.

External links

• KCNIP2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.