TRPV5

Transient receptor potential cation channel, subfamily V, member 5

Identifiers

TRPV5 ; CAT2; ECAC1; OTRPC3

External IDs

OMIM: 606679 MGI: 2429764 HomoloGene: 10520 IUPHAR: 511 ChEMBL: 1628474 GeneCards: TRPV5 Gene

Gene ontology
Molecular function	â€¢ calcium channel activity â€¢ protein binding â€¢ calmodulin binding
Cellular component	â€¢ plasma membrane â€¢ integral component of plasma membrane â€¢ apical plasma membrane
Biological process	â€¢ calcium ion transport â€¢ ion transmembrane transport â€¢ protein tetramerization â€¢ transmembrane transport â€¢ calcium ion transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
142.91 â€“ 142.93 Mb

Chr 6:
41.65 â€“ 41.68 Mb

PubMed search

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.^[1]^[2]^[3]

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺.^[4] Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consequentual hyperparathyroidism, and bone loss.^[5]

Function

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.^[6]

Interactions

TRPV5 has been shown to interact with S100A10.^[7]

References

â†‘ MÃ¼ller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem. Biophys. Res. Commun. 275 (1): 47â€“52. doi:10.1006/bbrc.2000.3227. PMID 10944439.
â†‘ MÃ¼ller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, GarcÃa-Nieto V, Claverie-MartÃn F, Bindels RJ (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics 67 (1): 48â€“53. doi:10.1006/geno.2000.6203. PMID 10945469.
â†‘ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427â€“50. doi:10.1124/pr.57.4.6. PMID 16382100.
â†‘ Hoenderop JG, Nilius B, Bindels RJ (2002). "Molecular mechanism of active Ca2+ reabsorption in the distal nephron". Annu. Rev. Physiol. 64: 529â€“49. doi:10.1146/annurev.physiol.64.081501.155921. PMID 11826278.
â†‘ Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van der Kemp AW, MÃ©rillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ (2003). "Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5". J. Clin. Invest. 112 (12): 1906â€“14. doi:10.1172/JCI19826. PMC 297001. PMID 14679186.
â†‘ "Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5".
â†‘ van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ (Apr 2003). "Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex". EMBO J. 22 (7): 1478â€“87. doi:10.1093/emboj/cdg162. PMC 152906. PMID 12660155.

External links

TRPV5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vÎ± 1.1 1.2 1.3 1.4 N-type/Ca_vÎ±2.2 P-type/Ca_vÎ± 2.1 Q-type/Ca_vÎ±2.1 R-type/Ca_vÎ±2.3 T-type/Ca_vÎ± 3.1 3.2 3.3 Î±₂Î´-subunits 1 2 Î²-subunits Î²1 Î²2 Î²3 Î²4 Î³-subunits Î³1 Î³2 Î³3 Î³4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel Î± Î² Î³ Î´

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vÎ± 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vÎ² 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel Î±1 Î²1 Î²2 Î²3 Î²4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vÎ±1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vÎ±7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vÎ² 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl^âˆ’: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	Î± 1 2 3 4 Î² 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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TRPV5

Function

Interactions

See also

References

Further reading

External links