Aquaporin 1

Aquaporin 1 (Colton blood group)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FQY​, 1H6I​, 1IH5​, 4CSK​
Identifiers
Symbols	AQP1 ; AQP-CHIP; CHIP28; CO
External IDs	OMIM: 107776 MGI: 103201 HomoloGene: 68051 IUPHAR: 688 GeneCards: AQP1 Gene
Gene ontology Molecular function • intracellular cGMP activated cation channel activity • potassium channel activity • water transmembrane transporter activity • protein binding • ammonium transmembrane transporter activity • potassium ion transmembrane transporter activity • glycerol transmembrane transporter activity • water channel activity • glycerol channel activity • transmembrane transporter activity • nitric oxide transmembrane transporter activity • carbon dioxide transmembrane transporter activity • ephrin receptor binding Cellular component • nucleus • cytoplasm • plasma membrane • integral component of plasma membrane • brush border • basal plasma membrane • basolateral plasma membrane • apical plasma membrane • symbiont-containing vacuole • symbiont-containing vacuole membrane • brush border membrane • nuclear membrane • sarcolemma • axon terminus • apical part of cell • extracellular exosome Biological process • renal water homeostasis • glomerular filtration • renal water transport • cGMP biosynthetic process • potassium ion transport • water transport • cell volume homeostasis • cellular water homeostasis • positive regulation of lamellipodium assembly • positive regulation of epithelial cell migration • carbon dioxide transport • ammonium transport • bicarbonate transport • glycerol transport • sensory perception of pain • cellular homeostasis • lateral ventricle development • pancreatic juice secretion • nitric oxide transport • establishment or maintenance of actin cytoskeleton polarity • cerebrospinal fluid secretion • secretory granule organization • cellular response to stress • cellular response to UV • transepithelial water transport • carbon dioxide transmembrane transport • wound healing • odontogenesis • response to drug • hyperosmotic salinity response • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to estrogen • lipid digestion • small molecule metabolic process • positive regulation of angiogenesis • positive regulation of saliva secretion • positive regulation of fibroblast proliferation • camera-type eye morphogenesis • multicellular organismal water homeostasis • corticotropin secretion • transmembrane transport • renal water absorption • cellular response to hydrogen peroxide • cellular response to inorganic substance • cellular response to mechanical stimulus • cellular response to copper ion • cellular response to mercury ion • cellular response to retinoic acid • cellular response to cAMP • cellular response to hypoxia • cellular response to salt stress • cellular hyperosmotic response • cellular response to dexamethasone stimulus • cellular response to nitric oxide • potassium ion transmembrane transport • metanephric descending thin limb development • metanephric proximal straight tubule development • metanephric proximal convoluted tubule segment 2 development • metanephric glomerulus vasculature development • ammonium transmembrane transport • maintenance of symbiont-containing vacuole by host • cation transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	358	11826
Ensembl	ENSG00000240583	ENSMUSG00000004655
UniProt	P29972	Q02013
RefSeq (mRNA)	NM_000385	NM_007472
RefSeq (protein)	NP_001171989	NP_031498
Location (UCSC)	Chr 7: 30.91 – 30.93 Mb	Chr 6: 55.34 – 55.35 Mb
PubMed search

Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.

AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.

It is not regulated by vasopressin (ADH).

Function

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.^[1]

See also

• Aquaporin
• Colton antigen system

References

1. "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

Further reading

• Knepper MA (1994). "The aquaporin family of molecular water channels.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6255–8. doi:10.1073/pnas.91.14.6255. PMC 44179. PMID 7517546.
• Borgnia M, Nielsen S, Engel A, Agre P (2000). "Cellular and molecular biology of the aquaporin water channels.". Annu. Rev. Biochem. 68: 425–58. doi:10.1146/annurev.biochem.68.1.425. PMID 10872456.
• Horster M (2001). "Embryonic epithelial membrane transporters.". Am. J. Physiol. Renal Physiol. 279 (6): F982–96. PMID 11097616.
• Yool AJ, Weinstein AM (2002). "New roles for old holes: ion channel function in aquaporin-1.". News Physiol. Sci. 17: 68–72. PMID 11909995.
• Mitra AK, Ren G, Reddy VS, Cheng A, Froger A (2002). "The architecture of a water-selective pore in the lipid bilayer visualized by electron crystallography in vitreous ice". Novartis Found. Symp. Novartis Foundation Symposia 245: 33–46; discussion 46–50; 165–8. doi:10.1002/0470868759.ch4. ISBN 978-0-470-86875-1. PMID 12027013.
• Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP (2006). "Role of RhAG and AQP1 in NH₃ and CO₂ gas transport in red cell ghosts: a stopped-flow analysis". Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 13 (1–2): 117–22. doi:10.1016/j.tracli.2006.03.004. PMID 16574458.
• Preston GM, Carroll TP, Guggino WB, Agre P (1992). "Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein". Science 256 (5055): 385–7. doi:10.1126/science.256.5055.385. PMID 1373524.
• Preston GM, Agre P (1992). "Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11110–4. doi:10.1073/pnas.88.24.11110. PMC 53083. PMID 1722319.
• Smith BL, Agre P (1991). "Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins". J. Biol. Chem. 266 (10): 6407–15. PMID 2007592.
• Denker BM, Smith BL, Kuhajda FP, Agre P (1988). "Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules". J. Biol. Chem. 263 (30): 15634–42. PMID 3049610.
• Zelinski T, Kaita H, Lewis M, Coghlan G, Philipps S, Belcher E, McAlpine PJ, Coopland G, Wong P (1988). "The Colton blood group locus. A linkage analysis". Transfusion 28 (5): 435–8. doi:10.1046/j.1537-2995.1988.28588337331.x. PMID 3166547.
• Preston GM, Jung JS, Guggino WB, Agre P (1994). "Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis". J. Biol. Chem. 269 (3): 1668–73. PMID 7507481.
• Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS (1994). "Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum". J. Cell Biol. 125 (4): 803–15. doi:10.1083/jcb.125.4.803. PMC 2120064. PMID 7514605.
• Li X, Yu H, Koide SS (1994). "The water channel gene in human uterus". Biochem. Mol. Biol. Int. 32 (2): 371–7. PMID 7517253.
• Walz T, Smith BL, Agre P, Engel A (1994). "The three-dimensional structure of human erythrocyte aquaporin CHIP". EMBO J. 13 (13): 2985–93. PMC 395186. PMID 7518771.
• Preston GM, Smith BL, Zeidel ML, Moulds JJ, Agre P (1994). "Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels". Science 265 (5178): 1585–7. doi:10.1126/science.7521540. PMID 7521540.
• Smith BL, Preston GM, Spring FA, Anstee DJ, Agre P (1994). "Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens". J. Clin. Invest. 94 (3): 1043–9. doi:10.1172/JCI117418. PMC 295159. PMID 7521882.
• van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS (1995). "Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels". Biochemistry 34 (7): 2212–9. doi:10.1021/bi00007a015. PMID 7532004.
• Keen TJ, Inglehearn CF, Patel RJ, Green ED, Peluso DC, Bhattacharya SS (1995). "Localization of the aquaporin 1 (AQP1) gene within a YAC contig containing the polymorphic markers D7S632 and D7S526". Genomics 25 (2): 599–600. doi:10.1016/0888-7543(95)80070-3. PMID 7540589.

External links

• Aquaporin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
• Gallery of Aquaporin Simulations

This article incorporates text from the United States National Library of Medicine, which is in the public domain.