ITPR1

Inositol 1,4,5-trisphosphate receptor, type 1
PDB rendering based on 1n4k.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1n4k​, 1xzz​
Identifiers
Symbols	ITPR1 ; ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29
External IDs	OMIM: 147265 MGI: 96623 HomoloGene: 1673 IUPHAR: 743 ChEMBL: 4046 GeneCards: ITPR1 Gene
Gene ontology Molecular function • intracellular ligand-gated calcium channel activity • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • protein binding • calcium ion transmembrane transporter activity • calcium channel inhibitor activity • phosphatidylinositol binding Cellular component • nuclear inner membrane • nucleolus • endoplasmic reticulum • endoplasmic reticulum membrane • calcineurin complex • postsynaptic density • membrane • integral component of membrane • sarcoplasmic reticulum • platelet dense granule membrane • platelet dense tubular network • platelet dense tubular network membrane Biological process • response to hypoxia • stimulatory C-type lectin receptor signaling pathway • energy reserve metabolic process • calcium ion transport • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • fibroblast growth factor receptor signaling pathway • post-embryonic development • platelet activation • endoplasmic reticulum calcium ion homeostasis • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • small molecule metabolic process • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • inositol phosphate-mediated signaling • regulation of insulin secretion • negative regulation of calcium-mediated signaling • voluntary musculoskeletal movement • release of sequestered calcium ion into cytosol • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3708	16438
Ensembl	ENSG00000150995	ENSMUSG00000030102
UniProt	Q14643	P11881
RefSeq (mRNA)	NM_001099952	NM_010585
RefSeq (protein)	NP_001093422	NP_034715
Location (UCSC)	Chr 3: 4.49 – 4.85 Mb	Chr 6: 108.21 – 108.55 Mb
PubMed search

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.^{[1][2][3][4][5]}

Interactions

ITPR1 has been shown to interact with:

• AHCYL1,^[6]
• CA8,^[7]
• EPB41L1^[8]
• FKBP1A,^[9][10]
• MRVI1,^[11]
• PRKG1,^[11]
• RHOA,^[12] and
• TRPC4.^[13][14]

See also

• Inositol triphosphate
• Inositol triphosphate receptor

References

1. Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T (Sep 1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". The Biochemical Journal 302 (Pt 3): 781–90. doi:10.1042/bj3020781. PMC 1137299. PMID 7945203.
2. Nucifora FC, Li SH, Danoff S, Ullrich A, Ross CA (Sep 1995). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant". Brain Research. Molecular Brain Research 32 (2): 291–6. doi:10.1016/0169-328X(95)00089-B. PMID 7500840.
3. van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (Jun 2007). "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans". PLoS Genetics 3 (6): e108. doi:10.1371/journal.pgen.0030108. PMC 1892049. PMID 17590087.
4. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (Jan 2008). "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". Journal of Medical Genetics 45 (1): 32–5. doi:10.1136/jmg.2007.053942. PMID 17932120.
5. "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1".
6. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". The Journal of Biological Chemistry 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
7. Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". The Biochemical Journal 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. PMC 1223404. PMID 12611586.
8. Maximov A, Tang TS, Bezprozvanny I (Feb 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Molecular and Cellular Neurosciences 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536.
9. MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG (Dec 2005). "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science 118 (Pt 23): 5443–51. doi:10.1242/jcs.02657. PMID 16278292.
10. Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
11. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
12. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB (Aug 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry 278 (35): 33492–500. doi:10.1074/jbc.M302401200. PMID 12766172.
13. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576.
14. Mery L, Magnino F, Schmidt K, Krause KH, Dufour JF (Jan 2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Letters 487 (3): 377–83. doi:10.1016/s0014-5793(00)02362-0. PMID 11163362.

Further reading

• Stove V, Verhasselt B (Jan 2006). "Modelling thymic HIV-1 Nef effects". Current HIV Research 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
• Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR (Oct 1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells". The Journal of Biological Chemistry 270 (40): 23310–6. doi:10.1074/jbc.270.40.23310. PMID 7559486.
• Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR (Feb 1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation". The Journal of Biological Chemistry 270 (6): 2833–40. doi:10.1074/jbc.270.6.2833. PMID 7852357.
• Wojcikiewicz RJ, Furuichi T, Nakade S, Mikoshiba K, Nahorski SR (Mar 1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation". The Journal of Biological Chemistry 269 (11): 7963–9. PMID 8132516.
• Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry 269 (12): 8701–7. PMID 8132598.
• Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH (Nov 1995). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476.
• Yan J, Khanna KK, Lavin MF (May 1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation". International Journal of Radiation Biology 69 (5): 539–46. doi:10.1080/095530096145544. PMID 8648241.
• Quinton TM, Dean WL (Jul 1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets". Biochemical and Biophysical Research Communications 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116.
• Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
• Deelman LE, Jonk LJ, Henning RH (Jan 1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor". Gene 207 (2): 219–25. doi:10.1016/S0378-1119(97)00630-6. PMID 9511764.
• Martin C, Chapman KE, Seckl JR, Ashley RH (Jul 1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum". Neuroscience 85 (1): 205–16. doi:10.1016/S0306-4522(97)00612-X. PMID 9607712.
• Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
• Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S (Dec 1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels". Nature 396 (6710): 478–82. doi:10.1038/24890. PMID 9853757.
• Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG (Apr 1999). "Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi". The Journal of Cell Biology 145 (2): 279–89. doi:10.1083/jcb.145.2.279. PMC 2133108. PMID 10209024.
• Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Mayne M, Holden CP, Nath A, Geiger JD (Jun 2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
• Tanimura A, Tojyo Y, Turner RJ (Sep 2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". The Journal of Biological Chemistry 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.

External links

• ITPR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 15