CLCN6

Chloride channel, voltage-sensitive 6
Identifiers
Symbols	CLCN6 ; CLC-6
External IDs	OMIM: 602726 MGI: 1347049 HomoloGene: 985 IUPHAR: 705 GeneCards: CLCN6 Gene
Gene ontology Molecular function • voltage-gated chloride channel activity • ATP binding • antiporter activity Cellular component • lysosomal membrane • endosome membrane • integral component of membrane Biological process • chloride transport • cell volume homeostasis • signal transduction • response to mechanical stimulus • ion transmembrane transport • transmembrane transport • regulation of anion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1185	26372
Ensembl	ENSG00000011021	ENSMUSG00000029016
UniProt	P51797	O35454
RefSeq (mRNA)	NM_001256959	NM_011929
RefSeq (protein)	NP_001243888	NP_036059
Location (UCSC)	Chr 1: 11.81 – 11.84 Mb	Chr 4: 148 – 148.04 Mb
PubMed search

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.^[1][2]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.^[2]

See also

• Chloride channel

References

1. Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009.
2. "Entrez Gene: CLCN6 chloride channel 6".

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nomura N, Nagase T, Miyajima N; et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Eggermont J, Buyse G, Voets T; et al. (1997). "Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific". Biochem. J. 325 ( Pt 1) (Pt 1): 269–76. PMC 1218554. PMID 9224655.
• Eggermont J (1998). "The exon-intron architecture of human chloride channel genes is not conserved". Biochim. Biophys. Acta 1397 (2): 156–60. doi:10.1016/s0167-4781(98)00014-1. PMID 9565675.
• Lamb FS, Clayton GH, Liu BX; et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. doi:10.1006/jmcc.1998.0901. PMID 10198195.
• Kornak U, Bösl MR, Kubisch C (1999). "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)". Biochim. Biophys. Acta 1447 (1): 100–6. doi:10.1016/s0167-4781(99)00128-1. PMID 10500249.
• Lamb FS, Graeff RW, Clayton GH; et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. doi:10.1165/ajrcmb.24.4.4114. PMID 11306429.
• Tran P, Leclerc D, Chan M; et al. (2003). "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms". Mamm. Genome 13 (9): 483–92. doi:10.1007/s00335-002-2167-6. PMID 12370778.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

External links

• CLCN6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.