TPCN1
| Two pore segment channel 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TPCN1 ; TPC1 | ||||||||||||
| External IDs | OMIM: 609666 MGI: 2182472 HomoloGene: 9905 IUPHAR: 392 GeneCards: TPCN1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 53373 | 252972 | |||||||||||
| Ensembl | ENSG00000186815 | ENSMUSG00000032741 | |||||||||||
| UniProt | Q9ULQ1 | Q9EQJ0 | |||||||||||
| RefSeq (mRNA) | NM_001143819 | NM_145853 | |||||||||||
| RefSeq (protein) | NP_001137291 | NP_665852 | |||||||||||
| Location (UCSC) |
Chr 12: 113.22 – 113.3 Mb |
Chr 5: 120.53 – 120.59 Mb | |||||||||||
| PubMed search | |||||||||||||
Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene.[1] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[2][3][4]
See also
References
- ↑ "Entrez Gene: two pore segment channel 1".
- ↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (October 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- ↑ Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochem. Biophys. Res. Commun. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632.
- ↑ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
Further reading
- Ishibashi K, Suzuki M, Imai M (2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels.". Biochem. Biophys. Res. Commun. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632.
- Hirosawa M, Nagase T, Ishikawa K, et al. (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Calcraft PJ, Ruas M, Pan Z, et al. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels.". Nature 459 (7246): 596–600. doi:10.1038/nature08030. PMC 2761823. PMID 19387438.
- Nakajima D, Okazaki N, Yamakawa H, et al. (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
External links
- TPCN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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