CACNA2D2

Calcium channel, voltage-dependent, alpha 2/delta subunit 2
Identifiers
Symbols	CACNA2D2 ; CACNA2D
External IDs	OMIM: 607082 MGI: 1929813 HomoloGene: 4400 ChEMBL: 3896 GeneCards: CACNA2D2 Gene
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium channel regulator activity • metal ion binding Cellular component • plasma membrane • voltage-gated calcium channel complex Biological process • energy reserve metabolic process • neuromuscular junction development • regulation of ion transmembrane transport • regulation of multicellular organism growth • small molecule metabolic process • positive regulation of organ growth • muscle fiber development • regulation of insulin secretion • regulation of calcium ion transport • rhythmic synaptic transmission • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9254	56808
Ensembl	ENSG00000007402	ENSMUSG00000010066
UniProt	Q9NY47	Q6PHS9
RefSeq (mRNA)	NM_001005505	NM_001174047
RefSeq (protein)	NP_001005505	NP_001167518
Location (UCSC)	Chr 3: 50.36 – 50.5 Mb	Chr 9: 107.4 – 107.53 Mb
PubMed search

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.^[1]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[1]

See also

• Voltage-dependent calcium channel

References

1. "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".

Further reading

• Donato R, Page KM, Koch D; et al. (2006). "The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression". J. Neurosci. 26 (48): 12576–86. doi:10.1523/JNEUROSCI.3080-06.2006. PMC 1797058. PMID 17135419.
• Carboni GL, Gao B, Nishizaki M; et al. (2003). "CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity". Oncogene 22 (4): 615–26. doi:10.1038/sj.onc.1206134. PMC 3484891. PMID 12555074.
• Honorio S, Gordon K, MacCartney D; et al. (2002). "Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene". Mol. Cell. Probes 15 (6): 391–3. doi:10.1006/mcpr.2001.0382. PMID 11851383.
• Angeloni D, Duh FM, Wei MF; et al. (2001). "A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3". Mol. Cell. Probes 15 (2): 125–7. doi:10.1006/mcpr.2000.0341. PMID 11292331.
• Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
• Gao B, Sekido Y, Maximov A; et al. (2000). "Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)". J. Biol. Chem. 275 (16): 12237–42. doi:10.1074/jbc.275.16.12237. PMC 3484885. PMID 10766861.
• Hobom M, Dai S, Marais E; et al. (2000). "Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit". Eur. J. Neurosci. 12 (4): 1217–26. doi:10.1046/j.1460-9568.2000.01009.x. PMID 10762351.
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

External links

• CACNA2D2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.