KCNK7

Potassium channel, two pore domain subfamily K, member 7
Identifiers
Symbols	KCNK7 ; K2p7.1; TWIK3
External IDs	OMIM: 603940 MGI: 1341841 HomoloGene: 43131 IUPHAR: 519 GeneCards: KCNK7 Gene
Gene ontology Molecular function • voltage-gated ion channel activity • potassium channel activity • potassium ion leak channel activity Cellular component • plasma membrane • integral component of plasma membrane Biological process • potassium ion transport • synaptic transmission • stabilization of membrane potential • regulation of ion transmembrane transport • potassium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10089	16530
Ensembl	ENSG00000173338	ENSMUSG00000024936
UniProt	Q9Y2U2	Q9Z2T1
RefSeq (mRNA)	NM_005714	NM_001004138
RefSeq (protein)	NP_005705	NP_034739
Location (UCSC)	Chr 11: 65.59 – 65.6 Mb	Chr 19: 5.7 – 5.71 Mb
PubMed search

Potassium channel, subfamily K, member 7, also known as KCNK7 or K_2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K_2P7.1 is a potassium channel containing two pore-forming P domains.^[1][2][3] Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.^[4]

See also

• Tandem pore domain potassium channel

References

1. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
2. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
4. "Entrez Gene: potassium channel".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
• Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
• Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.

External links

• KCNK7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNK7 human gene location in the UCSC Genome Browser.
• KCNK7 human gene details in the UCSC Genome Browser.