CLCA1

Chloride channel accessory 1
Identifiers
Symbols	CLCA1 ; CACC; CACC1; CLCRG1; CaCC-1; GOB5; hCLCA1; hCaCC-1
External IDs	OMIM: 603906 MGI: 1346342 HomoloGene: 984 GeneCards: CLCA1 Gene
Gene ontology Molecular function • intracellular calcium activated chloride channel activity • chloride channel activity • metallopeptidase activity • metal ion binding Cellular component • extracellular space • plasma membrane • integral component of plasma membrane • microvillus • secretory granule Biological process • proteolysis • transport • calcium ion transport • chloride transport • ion transmembrane transport • transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1179	23844
Ensembl	ENSG00000016490	ENSMUSG00000028255
UniProt	A8K7I4	Q9D7Z6
RefSeq (mRNA)	NM_001285	NM_017474
RefSeq (protein)	NP_001276	NP_059502
Location (UCSC)	Chr 1: 86.47 – 86.5 Mb	Chr 3: 145 – 145.03 Mb
PubMed search

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.^[1][2]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.^[2] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.^[3]

See also

• Chloride channel

References

1. Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
2. "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
3. Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading

• Hume JR, Duan D, Collier ML; et al. (2000). "Anion transport in heart". Physiol. Rev. 80 (1): 31–81. PMID 10617765.
• Pauli BU, Abdel-Ghany M, Cheng HC; et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
• Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Liu QH, Williams DA, McManus C; et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. doi:10.1067/mai.2002.121555. PMID 11842292.
• Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID 11994272.
• Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. doi:10.1074/jbc.M205307200. PMID 12110680.
• Loewen ME, Bekar LK, Gabriel SE; et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. doi:10.1016/S0006-291X(02)02498-1. PMID 12408984.
• Zhou Y, Shapiro M, Dong Q; et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Novartis Found. Symp. 248: 150–65; discussion 165–70, 277–82. doi:10.1002/0470860790.ch10. PMID 12568493.
• Abdel-Ghany M, Cheng HC, Elble RC; et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. doi:10.1074/jbc.M309086200. PMID 14512419.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hegab AE, Sakamoto T, Uchida Y; et al. (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. 41 (3): e27. doi:10.1136/jmg.2003.012484. PMC 1735703. PMID 14985398.
• Kamada F, Suzuki Y, Shao C; et al. (2005). "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. 5 (7): 540–7. doi:10.1038/sj.gene.6364124. PMID 15318163.
• Ritzka M, Stanke F, Jansen S; et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240.
• Gibson A, Lewis AP, Affleck K; et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. doi:10.1074/jbc.M504654200. PMID 15919655.
• Jeong SM, Park HK, Yoon IS; et al. (2005). "Cloning and expression of Ca²⁺-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID 16023076.

External links

• CLCA1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.