ITPR3

Inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbols	ITPR3 ; IP3R; IP3R3
External IDs	OMIM: 147267 MGI: 96624 HomoloGene: 1675 IUPHAR: 745 ChEMBL: 3904 GeneCards: ITPR3 Gene
Gene ontology Molecular function • inositol hexakisphosphate binding • intracellular ligand-gated calcium channel activity • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • protein binding • phosphatidylinositol binding • inositol 1,3,4,5 tetrakisphosphate binding • inositol 1,4,5 trisphosphate binding Cellular component • nuclear outer membrane • nucleoplasm • nucleolus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • plasma membrane • integral component of plasma membrane • brush border • membrane • platelet dense tubular network membrane • neuronal cell body • myelin sheath • receptor complex • apical part of cell Biological process • stimulatory C-type lectin receptor signaling pathway • energy reserve metabolic process • signal transduction • epidermal growth factor receptor signaling pathway • G-protein coupled receptor signaling pathway • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • blood coagulation • memory • fibroblast growth factor receptor signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • small molecule metabolic process • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • inositol phosphate-mediated signaling • regulation of insulin secretion • sensory perception of bitter taste • sensory perception of sweet taste • sensory perception of umami taste • protein homooligomerization • protein heterooligomerization • response to calcium ion • long-term synaptic potentiation • calcium ion transport into cytosol • calcium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3710	16440
Ensembl	ENSG00000096433	ENSMUSG00000042644
UniProt	Q14573	P70227
RefSeq (mRNA)	NM_002224	NM_080553
RefSeq (protein)	NP_002215	NP_542120
Location (UCSC)	Chr 6: 33.62 – 33.7 Mb	Chr 17: 27.06 – 27.12 Mb
PubMed search

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.^[1] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.^[2]

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.^[3]

See also

• Inositol trisphosphate receptor

References

1. "Entrez Gene: inositol 1".
2. Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734.
3. Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704.

Further reading

• Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor". J. Cell. Biochem. 104 (4): 1244–53. doi:10.1002/jcb.21704. PMC 2858327. PMID 18275062.
• Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population". J. Hum. Genet. 53 (2): 151–62. doi:10.1007/s10038-007-0233-3. PMID 18219441.
• Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca²⁺ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells". J. Mol. Cell. Cardiol. 45 (2): 176–84. doi:10.1016/j.yjmcc.2008.05.008. PMC 2566512. PMID 18586264.
• Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169.
• Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model". J. Neurosci. 29 (5): 1257–66. doi:10.1523/JNEUROSCI.4411-08.2009. PMC 2768402. PMID 19193873.
• Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca²⁺ release in naive CD4 T cells dictates their cytokine program". J. Immunol. 181 (12): 8315–22. doi:10.4049/jimmunol.181.12.8315. PMC 2756541. PMID 19050248.
• Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca²⁺-signaling complex in polarized epithelial cells. Role in apical Ca²⁺ influx". J. Biol. Chem. 280 (13): 12908–16. doi:10.1074/jbc.M410013200. PMID 15623527.
• Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca²⁺-binding proteins". EMBO J. 23 (2): 312–21. doi:10.1038/sj.emboj.7600037. PMC 1271747. PMID 14685260.
• Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca²⁺ signaling". J. Biol. Chem. 279 (12): 11967–75. doi:10.1074/jbc.M311456200. PMID 14707143.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden". Am. J. Hum. Genet. 79 (4): 614–27. doi:10.1086/507876. PMC 1592562. PMID 16960798.
• Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca²⁺ store". J. Pharmacol. Sci. 107 (2): 138–50. doi:10.1254/jphs.08021FP. PMID 18544901.
• Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca²⁺ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res. 295 (1): 102–18. doi:10.1016/j.yexcr.2003.12.025. PMID 15051494.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection". J. Neurosci. 28 (17): 4293–4. doi:10.1523/JNEUROSCI.0644-08.2008. PMID 18434505.
• Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun. 9 (3): 264–6. doi:10.1038/gene.2008.12. PMID 18340361.
• Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells". J. Biol. Chem. 283 (42): 28198–215. doi:10.1074/jbc.M802099200. PMC 2661391. PMID 18539593.
• Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport 18 (5): 447–50. doi:10.1097/WNR.0b013e32805868a6. PMID 17496801.
• Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site". J. Biol. Chem. 283 (46): 31284–8. doi:10.1074/jbc.C800184200. PMID 18826956.
• Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca²⁺ store release-induced Ca²⁺ entry in endothelial cells". Am. J. Physiol., Cell Physiol. 296 (3): C403–13. doi:10.1152/ajpcell.00470.2008. PMC 2660268. PMID 19052258.

External links

• ITPR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)