CLIC5

Chloride intracellular channel 5
Identifiers
Symbols	CLIC5 ; DFNB102; DFNB103; MST130; MSTP130
External IDs	OMIM: 607293 MGI: 1917912 HomoloGene: 987 GeneCards: CLIC5 Gene
Gene ontology Molecular function • glutathione transferase activity • voltage-gated ion channel activity • chloride channel activity • protein binding Cellular component • nucleus • Golgi apparatus • microtubule organizing center • cell cortex • actin cytoskeleton • stereocilium • chloride channel complex • extracellular exosome Biological process • diet induced thermogenesis • glutathione metabolic process • transport • chloride transport • female pregnancy • sensory perception of sound • protein localization • regulation of ion transmembrane transport • neuromuscular process controlling balance • auditory receptor cell stereocilium organization • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53405	224796
Ensembl	ENSG00000112782	ENSMUSG00000023959
UniProt	Q9NZA1	Q8BXK9
RefSeq (mRNA)	NM_001114086	NM_172621
RefSeq (protein)	NP_001107558	NP_766209
Location (UCSC)	Chr 6: 45.9 – 46.08 Mb	Chr 17: 44.19 – 44.28 Mb
PubMed search

Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene.^[1][2]

Function

Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.^[2] CLIC5 can form ion channel in bilayers and is regulated by actin.

See also

• Chloride channel

References

1. Berryman M, Bretscher A (Aug 2000). "Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli". Mol Biol Cell 11 (5): 1509–21. doi:10.1091/mbc.11.5.1509. PMC 14863. PMID 10793131.
2. "Entrez Gene: CLIC5 chloride intracellular channel 5".

Further reading

• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
• Suzuki T, Morita R, Sugimoto Y, et al. (2002). "Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5". Epilepsy Res. 50 (3): 265–75. doi:10.1016/S0920-1211(02)00052-9. PMID 12200217.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Berryman M, Bruno J, Price J, Edwards JC (2004). "CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo". J. Biol. Chem. 279 (33): 34794–801. doi:10.1074/jbc.M402835200. PMID 15184393.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gonzalez A, Ciobanu D, Sayers M, et al. (2007). "Gene transcript amplification from cell lysates in continuous-flow microfluidic devices". Biomedical microdevices 9 (5): 729–36. doi:10.1007/s10544-007-9083-1. PMID 17492382.
• Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J. 274 (24): 6306–6316. doi:10.1111/j.1742-4658.2007.06145.x. PMID 18028448.

External links

• CLIC5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.