Two-pore channel
two pore segment channel 1 | |
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Identifiers | |
Symbol | TPCN1 |
IUPHAR | 392 |
Entrez | 53373 |
HUGO | 18182 |
OMIM | 609666 |
RefSeq | NM_017901 |
UniProt | Q9ULQ1 |
Other data | |
Locus | Chr. 12 q24.21 |
two pore segment channel 2 | |
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Identifiers | |
Symbol | TPCN2 |
IUPHAR | 393 |
Entrez | 219931 |
HUGO | 20820 |
RefSeq | NM_139075 |
UniProt | Q8NHX9 |
Other data | |
Locus | Chr. 11 q13.1 |
Two-pore channels are a small family of putatively cation-selective ion channels, with two known paralogs in the human genome.[1] They are predicted to contain two KV-style six-transmembrane domains, suggesting they form a dimer in the membrane. These channels are closely related to CatSper channels and, more distantly, to TRP channels.
TCP channels are found in both animal and plant cells. In mammalian cells, recent evidence has identified the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP. The TPCN genes are distinct from the KCNK genes encoding the Tandem pore domain potassium channels.
References
- ↑ Yu, Frank H; Catterall, William A (2004). "The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis". Science STKE 253: re15. Retrieved 2016-02-02.
External links
- TPCN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- AtTPC1 channel, Arabidopsis at the US National Library of Medicine Medical Subject Headings (MeSH)
- "CatSper and Two-Pore Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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