AQP9

Aquaporin 9
Identifiers
Symbols	AQP9 ; AQP-9; HsT17287; SSC1
External IDs	OMIM: 602914 MGI: 1891066 HomoloGene: 41405 IUPHAR: 696 GeneCards: AQP9 Gene
Gene ontology Molecular function • amine transmembrane transporter activity • purine nucleobase transmembrane transporter activity • pyrimidine nucleobase transmembrane transporter activity • water transmembrane transporter activity • polyol transmembrane transporter activity • urea transmembrane transporter activity • water channel activity • glycerol channel activity • porin activity • carboxylic acid transmembrane transporter activity Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane • basolateral plasma membrane • intracellular membrane-bounded organelle Biological process • transport • water transport • purine nucleobase transport • immune response • response to osmotic stress • excretion • metabolic process • cellular water homeostasis • response to organic substance • canalicular bile acid transport • polyol transport • glycerol transport • amine transport • pyrimidine nucleobase transport • water homeostasis • ion transmembrane transport • response to mercury ion • carboxylic acid transport • transmembrane transport • cellular response to cAMP • urea transmembrane transport • pyrimidine-containing compound transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	366	64008
Ensembl	ENSG00000103569	ENSMUSG00000032204
UniProt	O43315	Q9JJJ3
RefSeq (mRNA)	NM_020980	NM_001271843
RefSeq (protein)	NP_066190	NP_001258772
Location (UCSC)	Chr 15: 58.14 – 58.19 Mb	Chr 9: 71.11 – 71.17 Mb
PubMed search

Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene.^[1]

The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a wide variety of noncharged solutes. AQP9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin 9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.^[1]

See also

• Aquaporin

References

1. "Entrez Gene: AQP9 aquaporin 9".

Further reading

• Ishibashi K, Kuwahara M, Gu Y; et al. (1998). "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol". Biochem. Biophys. Res. Commun. 244 (1): 268–74. doi:10.1006/bbrc.1998.8252. PMID 9514918.
• Tsukaguchi H, Shayakul C, Berger UV; et al. (1998). "Molecular characterization of a broad selectivity neutral solute channel". J. Biol. Chem. 273 (38): 24737–43. doi:10.1074/jbc.273.38.24737. PMID 9733774.
• Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (1999). "Functional and molecular characterization of the human neutral solute channel aquaporin-9". Am. J. Physiol. 277 (5 Pt 2): F685–96. PMID 10564231.
• Pastor-Soler N, Bagnis C, Sabolic I; et al. (2001). "Aquaporin 9 expression along the male reproductive tract". Biol. Reprod. 65 (2): 384–93. doi:10.1095/biolreprod65.2.384. PMID 11466204.
• Damiano A, Zotta E, Goldstein J; et al. (2001). "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta". Placenta 22 (8–9): 776–81. doi:10.1053/plac.2001.0717. PMID 11597198.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okada S, Misaka T, Matsumoto I; et al. (2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1–3): 157–62. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500.
• Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004). "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9". Biochem. Biophys. Res. Commun. 322 (3): 836–41. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang S, Chen J, Beall M; et al. (2005). "Expression of aquaporin 9 in human chorioamniotic membranes and placenta". Am. J. Obstet. Gynecol. 191 (6): 2160–7. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.
• Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Loitto VM, Huang C, Sigal YJ, Jacobson K (2007). "Filopodia are induced by aquaporin-9 expression". Exp. Cell Res. 313 (7): 1295–306. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.
• Warth A, Mittelbronn M, Hülper P; et al. (2007). "Expression of the water channel protein aquaporin-9 in malignant brain tumors". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633.

External links

• AQP9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.