HCN3

Hyperpolarization activated cyclic nucleotide gated potassium channel 3
Identifiers
Symbols	HCN3 ; KIAA1535; MGC131493
External IDs	OMIM: 609973 MGI: 1298211 HomoloGene: 22453 IUPHAR: 402 ChEMBL: 1795173 GeneCards: HCN3 Gene
Gene ontology Molecular function • voltage-gated sodium channel activity • voltage-gated potassium channel activity • cAMP binding Cellular component • plasma membrane • integral component of plasma membrane • dendrite • neuronal cell body • cone cell pedicle • synapse Biological process • synaptic transmission • regulation of ion transmembrane transport • sodium ion transmembrane transport • regulation of membrane potential • cellular response to cAMP • potassium ion transmembrane transport • response to cisplatin • cellular response to dopamine Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57657	15168
Ensembl	ENSG00000143630	ENSMUSG00000028051
UniProt	Q9P1Z3	O88705
RefSeq (mRNA)	NM_020897	NM_008227
RefSeq (protein)	NP_065948	NP_032253
Location (UCSC)	Chr 1: 155.28 – 155.29 Mb	Chr 3: 89.15 – 89.16 Mb
PubMed search

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.^[1][2]

See also

• Cyclic nucleotide-gated ion channel

References

1. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
2. "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

Further reading

• Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
• Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels.". Nature 393 (6685): 587–91. doi:10.1038/31255. PMID 9634236.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stieber J, Stöckl G, Herrmann S, et al. (2005). "Functional expression of the human HCN3 channel.". J. Biol. Chem. 280 (41): 34635–43. doi:10.1074/jbc.M502508200. PMID 16043489.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

External links

• HCN3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.