KCNK1

Potassium channel, two pore domain subfamily K, member 1
Crystallographic structure of human TWIK-1. The gray boxes indicate approximate location of the lipid bilayer.[1]
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3UKM​
Identifiers
Symbols	KCNK1 ; DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1; TWIK1
External IDs	OMIM: 601745 MGI: 109322 HomoloGene: 1691 IUPHAR: 513 GeneCards: KCNK1 Gene
Gene ontology Molecular function • inward rectifier potassium channel activity • voltage-gated potassium channel activity • potassium channel activity • sodium channel activity • potassium ion leak channel activity Cellular component • plasma membrane • integral component of plasma membrane • voltage-gated potassium channel complex • integral component of membrane • cytoplasmic membrane-bounded vesicle • apical plasma membrane • cell junction • dendrite • potassium channel complex • perikaryon • synapse • recycling endosome • inward rectifier potassium channel complex Biological process • potassium ion transport • synaptic transmission • stabilization of membrane potential • sodium ion transmembrane transport • regulation of resting membrane potential • potassium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3775	16525
Ensembl	ENSG00000135750	ENSMUSG00000033998
UniProt	O00180	O08581
RefSeq (mRNA)	NM_002245	NM_008430
RefSeq (protein)	NP_002236	NP_032456
Location (UCSC)	Chr 1: 233.61 – 233.67 Mb	Chr 8: 126 – 126.03 Mb
PubMed search

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.^[2][3][4]

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.^[4]

See also

• Tandem pore domain potassium channel

References

1. PDB: 3UKM​; Miller AN, Long SB (27 January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science 335 (6067): 432–6. doi:10.1126/science.1213274. PMID 22282804.
2. Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
4. "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

Further reading

• Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily". J. Mol. Med. 76 (1): 13–20. doi:10.1007/s109-1998-8100-0. PMID 9462864.
• Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. Renal Physiol. 279 (5): F793–801. PMID 11053038.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
• Lesage F, Guillemare E, Fink M, et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure". EMBO J. 15 (5): 1004–11. PMC 449995. PMID 8605869.
• Lesage F, Reyes R, Fink M, et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23): 6400–7. PMC 452465. PMID 8978667.
• Orias M, Velázquez H, Tung F, et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments". Am. J. Physiol. 273 (4 Pt 2): F663–6. PMID 9362344.
• Wang Z, Yue L, White M, et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle". Circulation 98 (22): 2422–8. doi:10.1161/01.cir.98.22.2422. PMID 9832487.
• Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear". Hear. Res. 181 (1–2): 20–6. doi:10.1016/S0378-5955(03)00162-X. PMID 12855359.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rajan S, Plant LD, Rabin ML, et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• KCNK1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.