ITPR2

Inositol 1,4,5-trisphosphate receptor, type 2

Identifiers

ITPR2 ; ANHD; CFAP48; INSP3R2; IP3R2

External IDs

OMIM: 600144 MGI: 99418 HomoloGene: 37593 IUPHAR: 744 ChEMBL: 2512 GeneCards: ITPR2 Gene

Gene ontology
Molecular function	• inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • calcium ion transmembrane transporter activity • phosphatidylinositol binding
Cellular component	• endoplasmic reticulum membrane • plasma membrane • cell cortex • membrane • integral component of membrane • platelet dense tubular network membrane • sarcoplasmic reticulum membrane • receptor complex
Biological process	• response to hypoxia • stimulatory C-type lectin receptor signaling pathway • energy reserve metabolic process • transport • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • fibroblast growth factor receptor signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • small molecule metabolic process • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • inositol phosphate-mediated signaling • regulation of insulin secretion • calcium ion transmembrane transport • cellular response to cAMP • cellular response to ethanol
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
26.34 – 26.83 Mb

Chr 6:
146.11 – 146.5 Mb

PubMed search

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene.^[1] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.^[2]

References

↑ "Entrez Gene: inositol 1".
↑ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734.

Jardín I, Lápez JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.". Cell. Signal. 20 (4): 737–47. doi:10.1016/j.cellsig.2007.12.010. PMID 18249094.
Wilker E, Mittleman MA, Litonjua AA, et al. (2009). "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.". Environ. Health Perspect. 117 (6): 935–40. doi:10.1289/ehp.0800279. PMC 2702409. PMID 19590686.
Rosado JA, Sage SO (2001). "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.". Biochem. J. 356 (Pt 1): 191–8. doi:10.1042/0264-6021:3560191. PMC 1221827. PMID 11336651.
van Es MA, Van Vught PW, Blauw HM, et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.". Lancet neurology 6 (10): 869–77. doi:10.1016/S1474-4422(07)70222-3. PMID 17827064.
Harzheim D, Movassagh M, Foo RS, et al. (2009). "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. doi:10.1073/pnas.0905485106. PMC 2708695. PMID 19549843.
Rosado JA, Sage SO (2000). "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.". Biochem. J. 350 Pt 3: 631–5. doi:10.1042/0264-6021:3500631. PMC 1221291. PMID 10970773.
Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results.". Arch. Gen. Psychiatry 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
Chiò A, Schymick JC, Restagno G, et al. (2009). "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.". Hum. Mol. Genet. 18 (8): 1524–32. doi:10.1093/hmg/ddp059. PMC 2664150. PMID 19193627.
Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.". Mod Rheumatol 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mery L, Magnino F, Schmidt K, et al. (2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.". FEBS Lett. 487 (3): 377–83. doi:10.1016/S0014-5793(00)02362-0. PMID 11163362.
Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells.". Cell Calcium 27 (6): 315–28. doi:10.1054/ceca.2000.0126. PMID 11013462.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.
Jurkovicova D, Sedlakova B, Lacinova L, et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.". Ann. N. Y. Acad. Sci. 1148: 421–7. doi:10.1196/annals.1410.034. PMID 19120137.
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.". J. Biol. Chem. 277 (2): 1340–8. doi:10.1074/jbc.M106609200. PMID 11694504.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tovey SC, Dedos SG, Taylor EJ, et al. (2008). "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.". J. Cell Biol. 183 (2): 297–311. doi:10.1083/jcb.200803172. PMC 2568025. PMID 18936250.
Johnson JM, Castle J, Garrett-Engele P, et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.

External links

ITPR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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ITPR2

See also

References

Further reading

External links