CLCA3

Chloride channel accessory 3, pseudogene
Identifiers
Symbols	CLCA3P ; CLCA3
External IDs	OMIM: 604337 GeneCards: CLCA3P Gene
Gene ontology Molecular function • transporter activity • voltage-gated ion channel activity • chloride channel activity • calcium channel activity Cellular component • extracellular region • extracellular space • plasma membrane • chloride channel complex Biological process • transport • ion transmembrane transport • regulation of ion transmembrane transport • transmembrane transport • calcium ion transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9629	23844
Ensembl	ENSG00000153923	ENSMUSG00000028255
UniProt	Q9Y6N3	Q9D7Z6
RefSeq (mRNA)	NM_004921	NM_017474
RefSeq (protein)	n/a	NP_059502
Location (UCSC)	Chr 1: 86.63 – 86.66 Mb	Chr 3: 144.67 – 144.7 Mb
PubMed search

Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.^[1] This protein is not expressed in humans but is in certain other species such as mouse.

Function

This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[2]

See also

• Chloride channel

References

1. Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca²⁺-activated Cl⁻ channels". Biochim. Biophys. Acta 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065.
2. Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu QH, Williams DA, McManus C; et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Pauli BU, Abdel-Ghany M, Cheng HC; et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
• Gruber AD, Pauli BU (1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31).". Genome 42 (5): 1030–2. doi:10.1139/gen-42-5-1030. PMID 10584316.

External links

• CLCA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.