HCN2

Hyperpolarization activated cyclic nucleotide gated potassium channel 2

PDB rendering based on 1q3e.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HCN2 ; BCNG-2; BCNG2; HAC-1
External IDs OMIM: 602781 MGI: 1298210 HomoloGene: 31022 IUPHAR: 401 ChEMBL: 1795172 GeneCards: HCN2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 610 15166
Ensembl ENSG00000099822 ENSMUSG00000020331
UniProt Q9UL51 O88703
RefSeq (mRNA) NM_001194 NM_008226
RefSeq (protein) NP_001185 NP_032252
Location (UCSC) Chr 19:
0.59 – 0.62 Mb		 Chr 10:
79.72 – 79.74 Mb
PubMed search

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[1][2][3][4]

Interactions

HCN2 has been shown to interact with HCN1[5][6] and HCN4.[5]

Function

The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[7]

See also

References

  1. ↑ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  2. ↑ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
  3. ↑ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
  4. ↑ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2".
  5. 1 2 Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
  6. ↑ Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
  7. ↑ "Gene find may lead to pills that kill chronic pain". The Times Of India. 10 September 2011.

Further reading

  • Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL (Dec 1998). "CCG repeats in cDNAs from human brain". Human Genetics 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901. 
  • Ludwig A, Zong X, Stieber J, Hullin R, Hofmann F, Biel M (May 1999). "Two pacemaker channels from human heart with profoundly different activation kinetics". The EMBO Journal 18 (9): 2323–9. doi:10.1093/emboj/18.9.2323. PMC 1171315. PMID 10228147. 
  • Vaccari T, Moroni A, Rocchi M, Gorza L, Bianchi ME, Beltrame M, DiFrancesco D (Sep 1999). "The human gene coding for HCN2, a pacemaker channel of the heart". Biochimica et Biophysica Acta 1446 (3): 419–25. doi:10.1016/s0167-4781(99)00092-5. PMID 10524219. 
  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Ulens C, Tytgat J (Mar 2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels". The Journal of Biological Chemistry 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998. 
  • Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718. 
  • Qu J, Altomare C, Bucchi A, DiFrancesco D, Robinson RB (Aug 2002). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflügers Archiv 444 (5): 597–601. doi:10.1007/s00424-002-0860-7. PMID 12194012. 
  • Sesti F, Rajan S, Gonzalez-Colaso R, Nikolaeva N, Goldstein SA (Apr 2003). "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel". Nature Neuroscience 6 (4): 353–61. doi:10.1038/nn1028. PMID 12640457. 
  • Stieber J, Thomer A, Much B, Schneider A, Biel M, Hofmann F (Sep 2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4". The Journal of Biological Chemistry 278 (36): 33672–80. doi:10.1074/jbc.M305318200. PMID 12813043. 
  • Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ (Jul 2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus". The Journal of Neuroscience 23 (17): 6826–36. PMID 12890777. 
  • Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435. 
  • Michels G, Er F, Khan I, Südkamp M, Herzig S, Hoppe UC (Feb 2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". Circulation 111 (4): 399–404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126. 
  • Akhavan A, Atanasiu R, Noguchi T, Han W, Holder N, Shrier A (Jul 2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". Journal of Cell Science 118 (Pt 13): 2803–12. doi:10.1242/jcs.02423. PMID 15961404. 
  • Calloe K, Elmedyb P, Olesen SP, Jorgensen NK, Grunnet M (Sep 2005). "Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels". Biophysical Journal 89 (3): 2159–69. doi:10.1529/biophysj.105.063792. PMC 1366717. PMID 15980171. 

External links

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