TRPC3

Transient receptor potential cation channel, subfamily C, member 3
Identifiers
Symbols	TRPC3 ; SCA41; TRP3
External IDs	OMIM: 602345 MGI: 109526 HomoloGene: 20708 IUPHAR: 488 GeneCards: TRPC3 Gene
Gene ontology Molecular function • calcium channel activity • protein binding • store-operated calcium channel activity • inositol 1,4,5 trisphosphate binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • calcium ion transport • manganese ion transport • axon guidance • blood coagulation • phototransduction • positive regulation of calcium ion transport into cytosol • platelet activation • response to ATP • ion transmembrane transport • cytosolic calcium ion homeostasis • response to calcium ion • transmembrane transport • calcium ion transmembrane transport • positive regulation of cardiac muscle hypertrophy in response to stress Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7222	22065
Ensembl	ENSG00000138741	ENSMUSG00000027716
UniProt	Q13507	B1ATV3
RefSeq (mRNA)	NM_001130698	NM_019510
RefSeq (protein)	NP_001124170	NP_062383
Location (UCSC)	Chr 4: 121.88 – 121.95 Mb	Chr 3: 36.62 – 36.69 Mb
PubMed search

Transient receptor potential cation channel, subfamily C, member 3, also known as TRPC3, is a human gene encoding a protein of the same name.

Interactions

TRPC3 has been shown to interact with TRPC1^[1][2] and TRPC6.^[3]

See also

• TRPC

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Lemmon MA (2005). "Pleckstrin homology domains: two halves make a hole?". Cell 120 (5): 574–6. doi:10.1016/j.cell.2005.02.023. PMID 15766521.
• Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
• Eder P, Poteser M, Groschner K (2007). "TRPC3: a multifunctional, pore-forming signalling molecule.". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 77–92. doi:10.1007/978-3-540-34891-7_4. ISBN 978-3-540-34889-4. PMID 17217051. |chapter= ignored (help)
• "Substance P modulation of TRPC3/ 7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity". European Journal of Neuroscience 31: 1219–1232. doi:10.1111/j.1460-9568.2010.07156.x.

References

1. Strübing, Carsten; Krapivinsky Grigory; Krapivinsky Luba; Clapham David E (Oct 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. (United States) 278 (40): 39014–9. doi:10.1074/jbc.M306705200. ISSN 0021-9258. PMID 12857742.
2. Xu, X Z; Li H S; Guggino W B; Montell C (Jun 1997). "Coassembly of TRP and TRPL produces a distinct store-operated conductance". Cell (UNITED STATES) 89 (7): 1155–64. doi:10.1016/S0092-8674(00)80302-5. ISSN 0092-8674. PMID 9215637.
3. Hofmann, Thomas; Schaefer Michael; Schultz Günter; Gudermann Thomas (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7461–6. doi:10.1073/pnas.102596199. ISSN 0027-8424. PMC 124253. PMID 12032305.

External links

• TRPC3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.