TRPM4

Transient receptor potential cation channel, subfamily M, member 4
Identifiers
Symbols	TRPM4 ; PFHB1B; TRPM4B
External IDs	OMIM: 606936 MGI: 1915917 HomoloGene: 23033 IUPHAR: 496 ChEMBL: 1628469 GeneCards: TRPM4 Gene
Gene ontology Molecular function • calcium activated cation channel activity • calcium channel activity • calmodulin binding • ATP binding Cellular component • nucleoplasm • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral component of membrane Biological process • adaptive immune response • dendritic cell chemotaxis • regulation of T cell cytokine production • positive regulation of cell proliferation • protein sumoylation • ion transmembrane transport • vasoconstriction • regulation of membrane potential • transmembrane transport • cardiac conduction • calcium ion transmembrane transport • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54795	68667
Ensembl	ENSG00000130529	ENSMUSG00000038260
UniProt	Q8TD43	Q7TN37
RefSeq (mRNA)	NM_001195227	NM_175130
RefSeq (protein)	NP_001182156	NP_780339
Location (UCSC)	Chr 19: 49.16 – 49.21 Mb	Chr 7: 45.3 – 45.33 Mb
PubMed search

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.^[1][2]

See also

• TRPM

References

1. Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
2. Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization". Cell 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988.
• Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671.
• Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
• Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4". Nat Immunol 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867.
• Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.

External links

• TRPM4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.