ACCN1

Acid sensing (proton gated) ion channel 2

Identifiers

ASIC2 ; ACCN; ACCN1; ASIC2a; BNC1; BNaC1; MDEG; hBNaC1

External IDs

OMIM: 601784 MGI: 1100867 HomoloGene: 137202 IUPHAR: 685 ChEMBL: 1628467 GeneCards: ASIC2 Gene

Gene ontology
Molecular function	• protein binding • ligand-gated sodium channel activity • ion gated channel activity
Cellular component	• plasma membrane • integral component of plasma membrane • neuronal cell body • dendritic spine
Biological process	• regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback • synaptic transmission • central nervous system development • peripheral nervous system development • phototransduction • sensory perception of sound • response to acidic pH • regulation of gene expression • monovalent inorganic cation transport • regulation of vasoconstriction • regulation of blood coagulation • ion transmembrane transport • regulation of ion transmembrane transport • protein localization to synapse • sodium ion transmembrane transport • regulation of membrane potential • negative regulation of apoptotic process • sensory perception of sour taste • detection of mechanical stimulus involved in sensory perception • positive regulation of synapse assembly • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
33.01 – 34.17 Mb

Chr 11:
80.88 – 81.97 Mb

PubMed search

Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ACCN1 gene.^[1]^[2] It is also known as an acid-sensing ion channel, ASIC2.^[3]

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.^[2]

References

↑ Waldmann R, Voilley N, Mattéï MG, Lazdunski M (Oct 1996). "The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798". Genomics 37 (2): 269–70. doi:10.1006/geno.1996.0558. PMID 8921408.
1 2 "Entrez Gene: ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin)".
↑ "ASIC2 acid sensing (proton gated) ion channel 2 [ Homo sapiens (human) ]". Retrieved 5 March 2015.

Price MP, Snyder PM, Welsh MJ (Apr 1996). "Cloning and expression of a novel human brain Na+ channel". The Journal of Biological Chemistry 271 (14): 7879–82. doi:10.1074/jbc.271.14.7879. PMID 8626462.
Waldmann R, Champigny G, Voilley N, Lauritzen I, Lazdunski M (May 1996). "The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans". The Journal of Biological Chemistry 271 (18): 10433–6. doi:10.1074/jbc.271.18.10433. PMID 8631835.
García-Añoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP (Feb 1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels". Proceedings of the National Academy of Sciences of the United States of America 94 (4): 1459–64. doi:10.1073/pnas.94.4.1459. PMC 19813. PMID 9037075.
Bassilana F, Champigny G, Waldmann R, de Weille JR, Heurteaux C, Lazdunski M (Nov 1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties". The Journal of Biological Chemistry 272 (46): 28819–22. doi:10.1074/jbc.272.46.28819. PMID 9360943.
Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". The Journal of Biological Chemistry 275 (37): 28519–25. doi:10.1074/jbc.M004114200. PMID 10842183.
Duggan A, Garcia-Anoveros J, Corey DP (Feb 2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". The Journal of Biological Chemistry 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (Feb 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". The Biochemical Journal 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (Dec 2004). "Stomatin modulates gating of acid-sensing ion channels". The Journal of Biological Chemistry 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860.
Saugstad JA, Roberts JA, Dong J, Zeitouni S, Evans RJ (Dec 2004). "Analysis of the membrane topology of the acid-sensing ion channel 2a". The Journal of Biological Chemistry 279 (53): 55514–9. doi:10.1074/jbc.M411849200. PMC 2928846. PMID 15504740.
Vila-Carriles WH, Kovacs GG, Jovov B, Zhou ZH, Pahwa AK, Colby G, Esimai O, Gillespie GY, Mapstone TB, Markert JM, Fuller CM, Bubien JK, Benos DJ (Jul 2006). "Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells". The Journal of Biological Chemistry 281 (28): 19220–32. doi:10.1074/jbc.M603100200. PMID 16704974.
Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, Simon RP (Aug 2007). "A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a". The Journal of Biological Chemistry 282 (31): 22668–77. doi:10.1074/jbc.M703624200. PMID 17548344.
Joch M, Ase AR, Chen CX, MacDonald PA, Kontogiannea M, Corera AT, Brice A, Séguéla P, Fon EA (Aug 2007). "Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels". Molecular Biology of the Cell 18 (8): 3105–18. doi:10.1091/mbc.E05-11-1027. PMC 1949385. PMID 17553932.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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ACCN1

Function

See also

References

Further reading