Heteromer

A heteromer is something that consists of different parts. Examples are:

Biology

Pharmacology

See also

References

  1. Medical dictionary
  2. Merriam-Webster Dictionary
  3. Gotti C, Moretti M, Gaimarri A, Zanardi A, Clementi F, Zoli M (October 2007). "Heterogeneity and complexity of native brain nicotinic receptors". Biochemical Pharmacology 74 (8): 1102–11. doi:10.1016/j.bcp.2007.05.023. PMID 17597586.
  4. Millar NS, Gotti C (January 2009). "Diversity of vertebrate nicotinic acetylcholine receptors". Neuropharmacology 56 (1): 237–46. doi:10.1016/j.neuropharm.2008.07.041. PMID 18723036.
  5. Collins AC, Salminen O, Marks MJ, Whiteaker P, Grady SR (2009). "The road to discovery of neuronal nicotinic cholinergic receptor subtypes". Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology 192 (192): 85–112. doi:10.1007/978-3-540-69248-5_4. ISBN 978-3-540-69246-1. PMID 19184647.
  6. Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court JA (August 2002). "Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders". Current Drug Targets. CNS and Neurological Disorders 1 (4): 387–97. doi:10.2174/1568007023339283. PMID 12769611.
  7. Nutt D (April 2006). "GABAA receptors: subtypes, regional distribution, and function". Journal of Clinical Sleep Medicine 2 (2): S7–11. PMID 17557501.
  8. Heldt SA, Ressler KJ (December 2007). "Forebrain and midbrain distribution of major benzodiazepine–sensitive GABAA receptor subunits in the adult C57 mouse as assessed with in situ hybridization". Neuroscience 150 (2): 370–85. doi:10.1016/j.neuroscience.2007.09.008. PMC 2292345. PMID 17950542.
  9. Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, Cunha RA, Ferré S, Franco R (February 2006). "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers". Journal of Neuroscience 26 (7): 2080–7. doi:10.1523/JNEUROSCI.3574-05.2006. PMID 16481441.
  10. Ferre S, Ciruela F, Borycz J, Solinas M, Quarta D, Antoniou K, Quiroz C, Justinova Z, Lluis C, Franco R, Goldberg SR (2008). "Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain". Frontiers in Bioscience 13 (13): 2391–9. doi:10.2741/2852. PMID 17981720.
  11. Rashid AJ, So CH, Kong MM, Furtak T, El-Ghundi M, Cheng R, O'Dowd BF, George SR (January 2007). "D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum". Proceedings of the National Academy of Sciences of the United States of America 104 (2): 654–9. doi:10.1073/pnas.0604049104. PMC 1766439. PMID 17194762.
  12. Marcellino D, Ferré S, Casadó V, Cortés A, Le Foll B, Mazzola C, Drago F, Saur O, Stark H, Soriano A, Barnes C, Goldberg SR, Lluis C, Fuxe K, Franco R (September 2008). "Identification of Dopamine D1–D3 Receptor Heteromers: INDICATIONS FOR A ROLE OF SYNERGISTIC D1–D3 RECEPTOR INTERACTIONS IN THE STRIATUM". The Journal of Biological Chemistry 283 (38): 26016–25. doi:10.1074/jbc.M710349200. PMC 2533781. PMID 18644790.
  13. Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Müller C, Woods AS, Hope BT, Ciruela F, Casadó V, Canela EI, Lluis C, Goldberg SR, Moratalla R, Franco R, Ferré S (2007). "Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids" (PDF). Neuropsychopharmacology 32 (11): 2249–59. doi:10.1038/sj.npp.1301375. PMID 17356572.
  14. Zezula J, Freissmuth M (March 2008). "The A2A-adenosine receptor: a GPCR with unique features?". British Journal of Pharmacology. 153 Suppl 1 (S1): S184–90. doi:10.1038/sj.bjp.0707674. PMC 2268059. PMID 18246094.
  15. Marcellino D, Carriba P, Filip M, Borgkvist A, Frankowska M, Bellido I, Tanganelli S, Müller CE, Fisone G, Lluis C, Agnati LF, Franco R, Fuxe K (April 2008). "Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis". Neuropharmacology 54 (5): 815–23. doi:10.1016/j.neuropharm.2007.12.011. PMID 18262573.
  16. Carriba P, Navarro G, Ciruela F, Ferré S, Casadó V, Agnati L, Cortés A, Mallol J, Fuxe K, Canela EI, Lluis C, Franco R (2008). "Detection of heteromerization of more than two proteins by sequential BRET-FRET". Nature Methods 5 (8): 727–33. doi:10.1038/nmeth.1229. PMID 18587404.
  17. Ferré S, Goldberg SR, Lluis C, Franco R (2009). "Looking for the role of cannabinoid receptor heteromers in striatal function". Neuropharmacology. 56 Suppl 1 (Suppl 1): 226–34. doi:10.1016/j.neuropharm.2008.06.076. PMC 2635338. PMID 18691604.
  18. Franco R, Casadó V, Cortés A, Mallol J, Ciruela F, Ferré S, Lluis C, Canela EI (March 2008). "G-protein-coupled receptor heteromers: function and ligand pharmacology". British Journal of Pharmacology. 153 Suppl 1 (S1): S90–8. doi:10.1038/sj.bjp.0707571. PMC 2268068. PMID 18037920.
  19. Fuxe K, Marcellino D, Rivera A, Diaz-Cabiale Z, Filip M, Gago B, Roberts DC, Langel U, Genedani S, Ferraro L, de la Calle A, Narvaez J, Tanganelli S, Woods A, Agnati LF (August 2008). "Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology". Brain Research Reviews 58 (2): 415–52. doi:10.1016/j.brainresrev.2007.11.007. PMID 18222544.
  20. Franco R, Casadó V, Cortés A, Pérez-Capote K, Mallol J, Canela E, Ferré S, Lluis C (August 2008). "Novel pharmacological targets based on receptor heteromers". Brain Research Reviews 58 (2): 475–82. doi:10.1016/j.brainresrev.2008.06.002. PMID 18620000.
  21. Fuxe K, Marcellino D, Woods AS, Giuseppina L, Antonelli T, Ferraro L, Tanganelli S, Agnati LF (January 2009). "Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia". Journal of Neural Transmission (Vienna, Austria : 1996) 116 (8): 923–39. doi:10.1007/s00702-008-0174-9. PMC 2953764. PMID 19156349.
  22. Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, Waldhoer M, Woods AS, Franco R (March 2009). "Building a new conceptual framework for receptor heteromers". Nature Chemical Biology 5 (3): 131–4. doi:10.1038/nchembio0309-131. PMC 2681085. PMID 19219011.
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