CHRNA7

Cholinergic receptor, nicotinic, alpha 7 (neuronal)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MAW​
Identifiers
Symbols	CHRNA7 ; CHRNA7-2; NACHRA7
External IDs	OMIM: 118511 MGI: 99779 HomoloGene: 593 IUPHAR: 468 ChEMBL: 2492 GeneCards: CHRNA7 Gene
Gene ontology Molecular function • beta-amyloid binding • acetylcholine-activated cation-selective channel activity • acetylcholine receptor activity • toxic substance binding • chloride channel regulator activity • acetylcholine-gated cation channel activity • acetylcholine binding • protein homodimerization activity Cellular component • plasma membrane • acetylcholine-gated channel complex • integral component of membrane • cell junction • neuron projection • synapse • postsynaptic membrane Biological process • activation of MAPK activity • response to hypoxia • ion transport • calcium ion transport • cellular calcium ion homeostasis • signal transduction • synaptic transmission • synaptic transmission, cholinergic • memory • positive regulation of cell proliferation • negative regulation of tumor necrosis factor production • ion transmembrane transport • response to nicotine • regulation of membrane potential • positive regulation of angiogenesis • cognition • cation transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1139	11441
Ensembl	ENSG00000175344	ENSMUSG00000030525
UniProt	P36544	P49582
RefSeq (mRNA)	NM_000746	NM_007390
RefSeq (protein)	NP_000737	NP_031416
Location (UCSC)	Chr 15: 32.03 – 32.17 Mb	Chr 7: 63.1 – 63.21 Mb
PubMed search

Neuronal acetylcholine receptor subunit alpha-7 is a protein that in humans is encoded by the CHRNA7 gene.^[1]

Function

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.^[2]

Interactions

CHRNA7 has been shown to interact with FYN.^[3]

Gene Expression

The CHRNA7 gene is primarily expressed in the posterior amygdalar nucleus and the field CA3 of Ammon's horn in the mouse, and in the mammillary body in humans. Gene expression patterns from the Allen Brain Atlases can be seen here.

See also

• Alpha-7 nicotinic receptor
• Nicotinic acetylcholine receptor
• Acetylcholine receptor

References

1. Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S (Jun 1994). "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)". Genomics 19 (2): 379–81. doi:10.1006/geno.1994.1075. PMID 8188270.
2. "Entrez Gene: CHRNA7 cholinergic receptor, nicotinic, alpha 7".
3. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (Apr 2001). "alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity". J. Biol. Chem. 276 (17): 13541–6. doi:10.1074/jbc.M008035200. PMID 11278378.

Further reading

• Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–7. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.
• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.
• Gallowitsch-Puerta M, Tracey KJ (2005). "Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor". Ann. N. Y. Acad. Sci. 1062: 209–19. doi:10.1196/annals.1358.024. PMID 16461803.
• Peng X, Katz M, Gerzanich V, Anand R, Lindstrom J (1994). "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes". Mol. Pharmacol. 45 (3): 546–54. PMID 8145738.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Elliott KJ, Ellis SB, Berckhan KJ, Urrutia A, Chavez-Noriega LE, Johnson EC, Veliçelebi G, Harpold MM (1996). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.
• Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, Johnson EC (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799.
• Gault J, Robinson M, Berger R, Drebing C, Logel J, Hopkins J, Moore T, Jacobs S, Meriwether J, Choi MJ, Kim EJ, Walton K, Buiting K, Davis A, Breese C, Freedman R, Leonard S (1998). "Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)". Genomics 52 (2): 173–85. doi:10.1006/geno.1998.5363. PMID 9782083.
• Curtis L, Blouin JL, Radhakrishna U, Gehrig C, Lasseter VK, Wolyniec P, Nestadt G, Dombroski B, Kazazian HH, Pulver AE, Housman D, Bertrand D, Antonarakis SE (1999). "No evidence for linkage between schizophrenia and markers at chromosome 15q13-14". Am. J. Med. Genet. 88 (2): 109–12. doi:10.1002/(SICI)1096-8628(19990416)88:2<109::AID-AJMG1>3.0.CO;2-3. PMID 10206225.
• Sander T, Schulz H, Vieira-Saeker AM, Bianchi A, Sailer U, Bauer G, Scaramelli A, Wienker TF, Saar K, Reis A, Janz D, Epplen JT, Riess O (1999). "Evaluation of a putative major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q14". Am. J. Med. Genet. 88 (2): 182–7. doi:10.1002/(SICI)1096-8628(19990416)88:2<182::AID-AJMG16>3.0.CO;2-Z. PMID 10206240.
• Sato KZ, Fujii T, Watanabe Y, Yamada S, Ando T, Kazuko F, Kawashima K (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173.
• Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB (2000). "beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology". J. Biol. Chem. 275 (8): 5626–32. doi:10.1074/jbc.275.8.5626. PMID 10681545.
• Schuller HM, Jull BA, Sheppard BJ, Plummer HK (2000). "Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders". Eur. J. Pharmacol. 393 (1-3): 265–77. doi:10.1016/S0014-2999(00)00094-7. PMID 10771023.
• Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (2001). "alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity". J. Biol. Chem. 276 (17): 13541–6. doi:10.1074/jbc.M008035200. PMID 11278378.
• Freedman R, Leonard S, Gault JM, Hopkins J, Cloninger CR, Kaufmann CA, Tsuang MT, Farone SV, Malaspina D, Svrakic DM, Sanders A, Gejman P (2001). "Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)". Am. J. Med. Genet. 105 (1): 20–2. doi:10.1002/1096-8628(20010108)105:1<20::AID-AJMG1047>3.0.CO;2-C. PMID 11424985.
• Engidawork E, Gulesserian T, Balic N, Cairns N, Lubec G (2001). "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 211–22. doi:10.1007/978-3-7091-6262-0_17. PMID 11771745.

External links

• CHRNA7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.