GABRG1
Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.[1] The protein encoded by this gene is a subunit of the GABAA receptor.[2]
Variants of this gene may be associated with alcohol dependence.[3]
References
- ↑ Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–61. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425.
- ↑ Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes". Mol. Neurobiol. 18 (1): 35–86. doi:10.1007/BF02741459. PMID 9824848.
- ↑ Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–9. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953.
Further reading
- Nymann-Andersen J, Wang H, Chen L; et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245.
- Iwakiri M, Mizukami K, Ikonomovic MD; et al. (2009). "An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.". Neuropathology 29 (3): 263–9. doi:10.1111/j.1440-1789.2008.00978.x. PMC 3078755. PMID 19019179.
- Craddock N, Jones L, Jones IR; et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.". Mol. Psychiatry 15 (2): 146–53. doi:10.1038/mp.2008.66. PMID 19078961.
- Ray LA, Hutchison KE (2009). "Associations among GABRG1, level of response to alcohol, and drinking behaviors.". Alcohol. Clin. Exp. Res. 33 (8): 1382–90. doi:10.1111/j.1530-0277.2009.00968.x. PMC 2965732. PMID 19426171.
- Ittiwut C, Listman J, Mutirangura A; et al. (2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–9. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953.
- Gratacòs M, Costas J, de Cid R; et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bonnert TP, McKernan RM, Farrar S; et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
- Guilmatre A, Dubourg C, Mosca AL; et al. (2009). "Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation". Arch. Gen. Psychiatry 66 (9): 947–56. doi:10.1001/archgenpsychiatry.2009.80. PMC 2958844. PMID 19736351.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ma DQ, Whitehead PL, Menold MM; et al. (2005). "Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism". Am. J. Hum. Genet. 77 (3): 377–88. doi:10.1086/433195. PMC 1226204. PMID 16080114.
- Covault J, Gelernter J, Jensen K; et al. (2008). "Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene". Neuropsychopharmacology 33 (4): 837–48. doi:10.1038/sj.npp.1301456. PMC 2743531. PMID 17507911.
- Enoch MA, Hodgkinson CA, Yuan Q; et al. (2009). "GABRG1 and GABRA2 as independent predictors for alcoholism in two populations". Neuropsychopharmacology 34 (5): 1245–54. doi:10.1038/npp.2008.171. PMC 2656604. PMID 18818659.
- Wilcox AS, Warrington JA, Gardiner K; et al. (1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–61. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425.
External links
- GABRG1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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